1 c-Cbl regulates nuclear β-catenin and angiogenesis through its Wnt-mediated phosphorylation Sowmya Shivanna 1 , Itrat Harrold 2 , Moshe Shashar 1 , Rosanna Meyer 3 , Chrystelle Kiang 4,5 , Jean Francis 1 , Qing Zhao 3 , Hui Feng 2 , Elazer R. Edelman 4,5 , Nader Rahimi 3 , Vipul C. Chitalia 1 Author affiliations: 1 Renal Section, Department of Medicine, Boston University School of Medicine, Boston, MA 02118, USA. 2 Department of Pharmacology, Boston University School of Medicine, Boston, MA 02118, USA 3 Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, MA 02118, USA 4 Institute of Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA 5 Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, USA *Corresponding author: Vipul Chitalia, M.D., Ph.D. Renal Section, Department of Medicine Boston University Medical Center Evans Biomedical Research Center, X-530 Boston, MA 02118, USA (P) 617-638-7330 (F) 617-638-7326 email: vichital@bu.edu Running title: Wnt-mediates c-Cbl phosphorylation to regulate active β-catenin http://www.jbc.org/cgi/doi/10.1074/jbc.M114.616623 The latest version is at JBC Papers in Press. Published on March 17, 2015 as Manuscript M114.616623 Copyright 2015 by The American Society for Biochemistry and Molecular Biology, Inc. by guest on March 5, 2016 http://www.jbc.org/ Downloaded from