1 Title: Targeting sphingosine kinase induces apoptosis and tumor regression for KSHV-associated primary effusion lymphoma Running Title: Targeting SphK induces apoptosis and PEL regression in vivo Authors: Zhiqiang Qin 1,7# , Lu Dai 2,7# , Jimena Trillo-Tinoco 3 , Can Senkal 4 , Wenxue Wang 5 , Tom Reske 2 , Karlie Bonstaff 2 , Luis Del Valle 3 , Paulo Rodriguez 1 , Erik Flemington 8 , Christina Voelkel-Johnson 6 , Charles D. Smith 5 , Besim Ogretmen 4 and Chris Parsons 1,2* Affiliations: Departments of Microbiology/Immunology/Parasitology 1 , Medicine 2 , and Pathology 3 , Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, 1700 Tulane Ave., New Orleans, LA 70112, USA Departments of Biochemistry/Molecular Biology 4 , Drug Discovery/Biomedical Sciences 5 , and Microbiology/Immunology 6 , Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas St., Charleston, SC 29425, USA 7 Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai 200120, China 8 Department of Microbiology, Tulane University School of Medicine, New Orleans, LA 70112 # These authors contributed equally to this work. * Correspondence: Mailing address: Suite 712, Louisiana Cancer Research Center, 1700 Tulane Ave., New Orleans, LA 70112, USA. Phone: (504)-210-3328. E- mail: cpars1@lsuhsc.edu (Dr. Chris Parsons). Keywords: KSHV, sphingosine kinase, S1P, lymphoma, HIV Financial information: This work was supported by independent grants from the National Institutes of Health (CA88932 and DE16572 to B. Ogretmen, and AI087167 to C. Parsons), a Center for Biomedical Research Excellence subaward (RR021970 to Z. Qin and L. Del Valle), the SOM Research Enhancement Funding (5497400038 to Z. Qin), the National Natural Science on March 7, 2016. © 2013 American Association for Cancer Research. mct.aacrjournals.org Downloaded from Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Author Manuscript Published OnlineFirst on October 18, 2013; DOI: 10.1158/1535-7163.MCT-13-0466