2001 pyrazine derivatives pyrazine derivatives R 0550 49 - 121 Sorbitol Dehydrogenase Inhibitors (SDIs): A New Potent, Enan- tiomeric SDI, 4-[2-(1R-Hydroxy-ethyl)-pyrimidin-4-yl]-piperazine-1- sulfonic Acid Dimethylamide. — Title compound (I) is found to be significantly more potent, both in vitro and in vivo, than the known analogue (II), — (MYLARI, BANAVARA L.; OATES, PETER J.; BEEBE, DAVID A.; BRACKETT, NATHANIEL S.; COUTCHER, JAMES B.; DINA, MICHAEL S.; ZEMBROWSKI, WILLIAM J.; J. Med. Chem. 44 (2001) 17,2695-2700; Dep. Cardiovasc.Metab. Dis., Pfizer Global Res.Dev., Pfizer Inc., Groton, CT 06340, USA; EN) 1