J OralMaxillofac Surg 68:243-253, 2010 Prevalence of Osteonecrosis of the Jaw in Patients With Oral Bisphosphonate Exposure Joan C.Lo,MD,* Felice S. O’Ryan,DDS,† Nancy P. Gordon,ScD,‡ Jingrong Yang, MA,§ Rita L.Hui,PharmD,MS,¶ Daniel Martin, DDS, 储 Matthew Hutchinson, DDS,# Phenius V. Lathon,** Gabriela Sanchez,†† Paula Silver,‡‡ Malini Chandra,§§ Carolyn A. McCloskey, MD,¶¶ Judy A.Staffa,PhD, 储储 Mary Willy, PhD,## Joe V.Selby, MD,MPH,*** and Alan S. Go,MD†††;for the Predicting Risk of Osteonecrosis of the Jaw with Oral Bisphosphonate Exposure (PROBE) Investigators *Research Scientist, Division of Research, KaiserPermanente Northern California, Oakland, and Associate Clinical Professor, De- partmentof Medicine,University ofCalifornia,San Francisco, School of Medicine, San Francisco, CA. †Director,Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, Oakland, CA. ‡Research Scientist, Division ofResearch, KaiserPermanente Northern California, Oakland, CA. §Data Consultant,Division of Research,Kaiser Permanente Northern California, Oakland, CA. ¶Outcomes Research Scientist, Pharmacy Outcomes Research Group,Drug Information Services, Kaiser Permanente California, Oakland, CA. 储 Resident, Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, and Department of Oral and Maxillofacial Surgery, Highland General Hospital, Oakland, CA. #Resident, Division of Maxillofacial Surgery, Kaiser Permanente Oakland Medical Center, and Department of Oral and Maxillofacial Surgery, Highland General Hospital, Oakland, CA. **ProjectManager,Division of Research,Kaiser Permanente Northern California, Oakland, CA. ††ProjectManager,Division of Research,KaiserPermanente Northern California, Oakland, CA. ‡‡ProjectManager,Division of Research,KaiserPermanente Northern California, Oakland, CA. §§Senior Consulting Data Analyst, Division ofResearch, Kaiser Permanente Northern California, Oakland, CA. ¶¶Epidemiologist, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemi- ology, Silver Spring, MD. 储储 Associate Director for Regulatory Research, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epidemiology, Silver Spring, MD. ##Senior Risk Analyst, US Food and Drug Administration, Center for Drug Evaluation and Research, Office of Surveillance and Epi- demiology, Silver Spring, MD. ***Director, Division ofResearch, Kaiser Permanente Northern California, Oakland, CA. †††Research Scientist, Division of Research, Kaiser Permanente Northern California, Oakland,and Associate Professor, Depart- ments of Medicine and Epidemiology and Biostatistics, University of California, San Francisco, School of Medicine, San Francisco, CA. This study was funded by the US Food and Drug Administration (HHSF223200510008C), the National Institute of Child Health and Human Development at the NationalInstitutesof Health (K12 HD052163), and the Kaiser Permanente Community Benefit Pro- gram;a portion of this study was also supported by the National Center for Research Resources at the National Institutes of Health (UCSF-CTSI UL1 RR024131). These data were presented in part at the 90th Annual Meeting of the Endocrine Society, San Francisco, CA, June 15-18, 2008. J. Lo previously received research funding from Novartis; D. Martin previously owned stock in Merck & Company, Incorpo- rated; a household family member of N. Gordon previously owned stock in Novartis Pharmaceuticals; a nonhousehold family member of F. O’Ryan is employed by Roche Laboratories; A. Go previously received research funding from Amgen and currently receives re- search funding from GlaxoSmithKline. The contents of this publication are solely the responsibility of the authors and do not represent the official views of the Food and Drug Administration or the National Institutes of Health. Address correspondence and reprint requests to Dr Lo: Division of Research, Kaiser Permanente Northern California, 2000 Broad- way, Oakland, CA 94612; e-mail: Joan.C.Lo@kp.org ©2010 American Association of Oral and Maxillofacial Surgeons 0278-2391/10/6802-0003$36.00/0 doi:10.1016/j.joms.2009.03.050 243