Genetic Loci Influencing C-reactive Protein Levels and Risk of Coronary Heart Disease Paul Elliott, FMedSci * , John C. Chambers, PhD * , and Weihua Zhang, PhD Faculty of Medicine, Imperial College London, London, UK Robert Clarke, MD and Jemma C. Hopewell, PhD Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford, UK John F. Peden, PhD Department of Cardiovascular Medicine and The Wellcome Trust Centre for Human Genetics, University of Oxford Jeanette Erdmann, PhD Universität zu Lübeck, Lübeck, Germany Peter Braund, MSc Department of Cardiovascular Sciences, University of Leicester, Leicester, UK James C. Engert, MD Departments of Medicine and Human Genetics, McGill University, Montreal, Quebec, Canada Derrick Bennett, PhD Clinical Trial Service Unit and Epidemiological Studies Unit, Oxford, UK Lachlan Coin, PhD and Deborah Ashby, PhD Faculty of Medicine, Imperial College London, London, UK Ioanna Tzoulaki, PhD, Ian J. Brown, PhD, and Shahrul Mt-Isa, BSc Faculty of Medicine, Imperial College London, London, UK Mark I. McCarthy, FMedSci Oxford Centre for Diabetes, Endocrinology and Metabolism and Oxford NIHR Biomedical Research Centre, Oxford, UK Leena Peltonen, MD, PhD Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK Nelson B. Freimer, MD Center for Neurobehavioral Genetics, UCLA, Los Angeles, USA Corresponding authors: Prof Paul Elliott, FMedSci, MRC-HPA Centre for Environment and Health, Department of Epidemiology and Public Health, Imperial College London, St Mary's Campus, Norfolk Place, London W2 1PG, UK (p.elliott@imperial.ac.uk), and Prof Jaspal Kooner, FRCP, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Road, London W12, UK (j.kooner@imperial.ac.uk).. * These authors contributed equally Author contributions PE and JSK had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. PE, JCC, JS, JSK designed the study and wrote the report. JCC, WZ, RC (Clarke), JH, LC, JT, IJB, SMI, DA, AR carried out the statistical and biochemical analyses. MIM, LP, NBF, NL, PF, DMW, PV, GW, MRJ, VM provided genome wide data and analysis. RC (Clarke), JH, JFP, DB, JE, PB, JCE, MF, AH, ASH, HS, SSA, RC (Collins), NJS, HW provided analysis of SNP data for cases and controls. Financial disclosures None declared. UKPMC Funders Group Author Manuscript JAMA. Author manuscript; available in PMC 2010 January 7. Published in final edited form as: JAMA. 2009 July 1; 302(1): 37–48. doi:10.1001/jama.2009.954. UKPMC Funders Group Author Manuscript UKPMC Funders Group Author Manuscript