1 Relationship between fenretinide pharmacokinetics, pharmacodynamics and plasma retinol reduction in neuroblastoma patients Franca Formelli 1 , Elena Cavadini 1 , Roberto Luksch 2 , Alberto Garaventa 3 , Valentina Appierto 1 , Stefano Persiani 4 . 1 Department of Experimental Oncology and Molecular Medicine and 2 Operative Unit of Pediatrics, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan; 3 Department of Pediatric Hematology/Oncology, Gaslini Children’s Hospital, Genova, and 4 Department of Translational Sciences and Pharmacokinetics, Rottapharm-Madaus, Monza, Milan, Italy Running title : Fenretinide pharmacokinetics and reduction of plasma retinol Keywords : fenretinide; retinol; pharmacodynamics; safety biomarker; retinoids; neuroblastoma. Grant support : Associazione Italiana per la Ricerca sul Cancro, Milan, Italy and Gateway for Cancer Research (formerly Cancer Treatment Research Foundation) Grant G-96-131. Requests for reprints: Franca Formelli, Fondazione IRCCS Istituto Nazionale dei Tumori, via Venezian 1, 20133 Milan, Italy. Phone: 39-02-2390-2706; Fax: 39-02-2390-2692; E- mail:franca.formelli@istitutotumori.m.it peer-00598971, version 1 - 8 Jun 2011 Author manuscript, published in "Cancer Chemotherapy and Pharmacology 66, 5 (2010) 993-998" DOI : 10.1007/s00280-010-1370-5