Gene Therapy Volume 12, Issue 22 (November 2005) Gene Therapy Progress and Prospects: Fetal gene therapy – first proofs of concept – some adverse effects C Coutelle, M Themis, S N Waddington, S M K Buckley, L G Gregory, M S Nivsarkar, A L David, D Peebles, B Weisz and C Rodeck Gene Ther 12: 1601-1607; advance online publication, September 1, 2005; doi:10.1038/sj.gt.3302632 Research Articles Oncolytic adenovirus that overproduces ADP and replicates selectively in tumors due to hTERT promoter-regulated E4 gene expression M Kuppuswamy, J F Spencer, K Doronin, A E Tollefson, W S M Wold and K Toth Gene Ther 12: 1608-1617; advance online publication, July 7, 2005; doi:10.1038/sj.gt.3302581 AAV2-mediated CLN2 gene transfer to rodent and non-human primate brain results in long-term TPP-I expression compatible with therapy for LINCL D Sondhi, D A Peterson, E L Giannaris, C T Sanders, B S Mendez, B De, A B Rostkowski, B Blanchard, K Bjugstad, J R Sladek Jr, D E Redmond Jr, P L Leopold, S M Kaminsky, N R Hackett and R G Crystal Gene Ther 12: 1618-1632; advance online publication, July 28, 2005; doi:10.1038/sj.gt.3302549 Eradication of hepatocellular carcinoma xenografts by radiolabelled, lipiodol-inducible gene therapy Y Kawashita, A Ohtsuru, F Miki, H Kuroda, M Morishita, Y Kaneda, K Hatsushiba, T Kanematsu and S Yamashita Gene Ther 12: 1633-1639; advance online publication, August 4, 2005; doi:10.1038/sj.gt.3302531