1 Loss of miR-101 Expression Promotes Wnt/ȕ-Catenin Signalling Pathway Activation and Malignancy in Colon Cancer Cells Antonio Strillacci 1 , Maria Chiara Valerii 1,2 , Pasquale Sansone 3,4 , Cinzia Caggiano 1 , Annamaria Sgromo 1 , Laura Vittori 2 , Michelangelo Fiorentino 5 , Gilberto Poggioli 2 , Fernando Rizzello 2 , Massimo Campieri 2 and Enzo Spisni 1 1 Department of Biology, University of Bologna, via Selmi 3, 40126 Bologna, Italy. 2 Department of Clinical Medicine, St. Orsola-Malpighi Hospital, via Massarenti 9, 40138 Bologna, Italy. 3 Department of Medicine, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. 4 Center for Applied Biomedical Research (CRBA), St. Orsola-Malpighi Hospital, via Massarenti 9, 40138 Bologna, Italy. 5 Pathology Unit, Addarii Institute of Oncology, St. Orsola- Malpighi Hospital, viale Ercolani 4/2, 40138 Bologna, Italy. Running Title: miR-101 repression promotes colorectal cancer Keywords: Colorectal Cancer; MiR-101; ȕ-Catenin; Hypoxia; EMT; Inflammation Corresponding Authors: Antonio Strillacci, Ph.D. (antonio.strillacci@unibo.it) and Enzo Spisni, Ph.D. (enzo.spisni@unibo.it); Department of Biology, University of Bologna, via Selmi 3, 40126 Bologna, Italy. Phone: +39 051 209 41 90; Fax: +39 051 209 42 86. Disclosure: No potential conflicts of interest exist. This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/path.4097.