memory complaints in the last 6 mounts, enrolled a well characterized AD assessment. Briefly, each participant undergoes an evaluation that includes a medical examination, interview, neuropsychological testing. To control the confounding effect of severity of impairment and stage of the Alzheimer’s Disease, our sample is limited to individuals with mild AD as shown by MMSE scores between 21-24 and Geriatric Depression Score over 14.For fluency and naming ability, we used categoric fluency (finding words in an- imal category among one minute), lexical fluency (finding words starting with K, A, S letters in one minute), and for confrontaional naming, short- ened Turkish form of Boston Naming Test is used. Results: Study group consisted of 26 female 10 male mild stage AD patients. Male patients, ranged in age from 64 to 80 (mean age 76.8 65.7); female patient , ranged in age from 65 to 89 (mean age 78.3 65.8). All participants were right handed. Average duration of education in male participants is 1263.4 years and in female participants is 6.864.1 years. Boston Naming Test (BNT) scores are calculated over the percentage of correct namings. The mean of the BNT in the study group is 74.95613.1. Categoric fluency mean of the study group is 10.4464.59 word. Lexical fluency is calculated over the sum of 3 letters (K,A,S) and the mean of the lexical fluency in the study group is 19.4369.52 word.There is a significant correlation between seman- tic fluency performance and confrontational naming in the current study group (p¼0.05). However this statistical correlation can not be observed be- tween phonemic fluency and confrontational naming scores. Recent neuro- imaging evidences support our findings. When the relation between semantic knowledge and abstraction task is examined, there is no significant relation between proverb abstraction and BNT whereas significant relation (p<0.01) found between Wechsler Similarites Subtest and BNT. These re- sults suggest that task of similarities abstraction is also related to semantic storage. Conclusions: Phonemic fluency requires a scanning strategy for lexical representations. However, category fluency requires an investigation of words from an exponential semantic storage. Because of this different structural and funcitonal demands, categorical fluency should be attributed to the semantic memory instead of executive functions. Because the semantic storage is already affected at the early stage of AD, patients seem to display insufficiency at abstraction when it is evaluated with paired- word similarities. P4-163 TRAJECTORIES OF COGNITIVE DECLINE IN VARIOUS TYPES OF DEMENTIA Lieke Smits 1 , Argonde Corien van Harten 2 , Yolande Pijnenburg 3 , Esther Koedam 1 , Nicole Sistermans 4 , Ilona Roos-Reuling 1 , Niels Prins 5 , Evelien Lemstra 6 , Philip Scheltens 7 , Wiesje M. van der Flier 3 , 1 VUMC Alzheimer Center Amsterdam, Amsterdam, Netherlands; 2 VUMC Alzheimer Center Amsterdam, Amsterdam, Netherlands; 3 VUMC, Amsterdam, Netherlands; 4 VUMC Alzheimer Center, Amsterdam, Netherlands; 5 VUMC Alzheimer Center, Amsterdam, Netherlands; 6 VUMC, Amsterdam, Netherlands; 7 VUMC, Amsterdam, Netherlands. Contact e-mail: l.smits@ vumc.nl Background: To investigate trajectories of cognitive decline in patients with various types of dementia compared to controls in a longitudinal study using an extensive neuropsychological test battery. Methods: In 282 patients with dementia (199 Alzheimer’s disease (AD), 10 vascular dementia (VaD), 26 dementia with Lewy bodies (DLB), 20 behavioural variant frontotemporal dementia (bvFTD), 15 language variant frontotem- poral dementia (lvFTD) and 12 patients with other types of dementia) and 112 controls we assessed global cognition with Mini-Mental State Exam- ination (MMSE) as well as five cognitive domains: memory, language, attention, executive and visuo-spatial functioning. All subjects had at least two neuropsychological assessments (median 2, range 2-7). Neuropsycho- logical data were standardized into z-scores using baseline performance of controls as reference. Linear mixed models were used to estimate baseline cognitive functioning and cognitive decline over time for each group, adjusted for age, gender and education. Results: At baseline,patients with dementia performed worse than controls in all cognitive domains (p<0.05), except visuo-spatial functioning, which was only impaired in patients with AD and DLB (p<0.001). During follow-up, patients with AD declined in all cognitive domains (p<0.001). DLB showed decline in every cognitive domain except language and MMSE. bvFTD showed rapid decline in memory, language, attention and executive functioning (all p<0.01), while visuo-spatial functioning remained quite stable. lvFTD declined mostly in attention and executive functioning, while VaD remained remarkably stable over time. Conclusions: We show cogni- tive trajectories of various types of dementia. These estimations of natural disease course have important value for the design of clinical trials as neuropsychological measures are increasingly being used as outcome measures. P4-164 QUALITATIVE THEMATIC ANALYSIS OF SUBJECTIVE MEMORY COMPLAINTS IN THE HEALTHY ELDERLYAND INDIVIDUALS WITH MCI Rachel Buckley 1 , Michael Saling 2 , David Ames 3 , Christopher Cleon Rowe 4 , Nicola T. Lautenschlager 5 , Paul Maruff 6 , Lance Macaulay 7 , Ralph Martins 8 , Cassandra Szoeke 9 , Colin Masters 10 , Stephanie Ruth Rainey-Smith 11 , Alan Rembach 12 , Greg Savage 13 , Kathryn A. Ellis 14 , 1 University of Melbourne, Melbourne, Victoria, Australia; 2 University of Melbourne, Melbourne, Australia; 3 National Ageing Research Institute Inc. (NARI), Parkville, Victoria, Australia; 4 Austin Hospital, Melbourne, Victoria, Australia; 5 University of Melbourne, Kew,Victoria, Australia; 6 CogState Ltd., Melbourne, Victoria, Australia; 7 CSIRO, Parkville,Victoria, Australia; 8 Edith Cowan University, Joondalup, Western Australia, Australia; 9 National Ageing Research Institute Inc. (NARI), Melbourne, Victoria, Australia; 10 University of Melbourne, Parkville, Victoria, Australia; 11 Edith Cowan University, Perth,Western Australia, Australia; 12 Mental Health Research Institute, Melbourne, Victoria, Australia; 13 Macquarie University, Sydney, New South Wales, Australia; 14 St Georges Hospital, Parkville, Victoria, Australia. Contact e-mail: r.buckley@student.unimelb.edu.au Background: Concerns of memory decline in older adults are the bridge connecting the patient to appropriate clinical services, and are therefore worthy of study. Current approaches to the measure of subjective memory complaints involves thematically unstructured questionnaires. These measures do not tap the complexity of memory complaints in a clinical presentation. Our aim was to study memory complaints through a quali- tative thematic analysis. Methods: A semi-structured interview, probing scenarios derived from clinical protocols, was administered to 80 healthy elderly controls (M age ¼75.6, SD ¼6.9) and 43 individuals with MCI (M age ¼79.6, SD ¼6.9). Responses were transcribed and coded, and were grouped according to their thematic content. Results: Eleven themes were extracted: frequency, sense of predomination, situational or general lapses, contextual recall, coping strategies, dismissive attitude, vagueness, impact on affect, sense of progression of memory decline, dependency on a significant other, and quality of the account. MCI participants complained significantly more about frequency, a sense of predomination, progression, dependency and impact on affect. They were also more dismissive of their memory symptoms (dismissive attitude), and displayed a poorer overall quality of their account. Individuals with MCI expressed more maladaptive coping strategies, with poorer contextualisation of their recent memory lapses. MCI participants were approximately four times more likely to exhibit maladaptive coping strategies, and twice as likely to express a sense of progression. Healthy controls were 1.6 times more likely, on the other hand, to complain of poorer attentional focus (vagueness). Conclusions: This is the first thematic analysis of memory complaints in the elderly. While most themes were elevated in individuals with MCI, we found certain complaints more effectively differentiated between the diagnostic categories. Complaints of vagueness were more likely to be expressed in healthy elderly individuals, perhaps driven by affective or stress-related factors. MCI individuals were more likely to express maladaptive coping Poster Presentations: P4 P849