Clinical Study The Effect of Intravenous Magnesium Sulfate Infusion on Sensory Spinal Block and Postoperative Pain Score in Abdominal Hysterectomy Fatih Kahraman 1 and Ahmet Eroglu 2 1 Private Guven Hospital, Anesthesiology, Trabzon 61000, Turkey 2 Karadeniz Technical University, Trabzon 61000, Turkey Correspondence should be addressed to Fatih Kahraman; yilmazdane@hotmail.com Received 3 December 2013; Accepted 20 February 2014; Published 19 March 2014 Academic Editor: Engin Erturk Copyright © 2014 F. Kahraman and A. Eroglu. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Aim. he aim of this study was to investigate the efect of i.v. infusion of magnesium sulphate during spinal anesthesia on duration of spinal block and postoperative pain. Methods. Forty ASA physical status I and status II, aged between 18 and 65, female patients undergoing abdominal hysterectomy under spinal anesthesia were enrolled in this study. Patients in the magnesium group (Group M, n = 20) received magnesium sulphate 65 mg kg -1 infusion in 250 mL 5% dextrose at 3.5 mL/min rate, and control group (Group C, n = 20) received at the same volume of saline during operation in a double-blind randomized manner. Duration of sensory and motor block, systolic, diastolic, and mean arterial blood pressures, heart rates, pain scores (VAS values), and side efects were recorded for each patient. Blood and CSF samples were taken for analysis of magnesium concentrations. Results. Regression of sensorial block was longer in Group M when compared with that in Group C (175 ± 39 versus 136 ± 32 min) (P < 0.01). he VAS scores were lower in Group M than those in Group C at the 2 time points postoperatively (P < 0.01). Conclusion. 65 mg kg -1 of magnesium sulphate i.v. infusion under spinal anesthesia prolongs spinal sensorial block duration and decreases pain VAS scores without complication in patients undergoing abdominal hysterectomy. 1. Introduction Magnesium sulphate has been used as an adjuvant for perioperative analgesia [1–4]. Many clinical studies have demonstrated that i.v. magnesium infusion during general anesthesia reduced anesthetic requirement and postoperative analgesic consumption [1–9]. Relatively few studies have been investigated on the efects of magnesium sulphate infusion during spinal anesthesia [10–12]. A previous study demonstrated that i.v. magnesium sulphate infusion during spinal anesthesia improves postoperative analgesia in total hip replacement [12]. Apan and colleagues [10] reported that magnesium sulphate infusion started immediately ater the spinal anesthesia and extended postoperatively for 24 h reduced analgesic consumption without any efect on spinal block in minor surgical procedures. hus, the efect of mag- nesium infusion during spinal anesthesia on postoperative analgesia and duration of spinal block have not been fully determined yet. he aim of this study was to investigate the efect of i.v. infusion of magnesium sulphate during spinal anesthesia on postoperative pain and duration of spinal block in abdominal hysterectomy. 2. Materials and Methods he study protocol was approved by the Institutional Ethics Committee and written informed consent was obtained from all patients. Forty ASA physical status I and status II, aged between 18 and 65 female patients undergoing abdominal Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 236024, 5 pages http://dx.doi.org/10.1155/2014/236024