Matters Fibronectin Patterning of Viscous Polymer 5lms by Microcontact Printing ! Chemical Biophysics, Cell biology, Biochemistry " Standalone observation # Standard Data $ Sandipan Dawn , Jacob John , Kenneth Carter , Harry Bermudez , Andreas P Kourouklis % & Polymer Science and Engineering, University of Massachusetts, Amherst; Bioengineering, University of Illinois Urbana-Champaign ' Submitted Dec 05, 2015 → Published Mar 08, 2016 (3 months) Abstract In working towards the goal of mimicking multiple features of the extracellular matrix (ECM), we developed a strategy to create adhesive protein patterns on polymer films with tunable viscous characteristics. The block copolymer films are generated by interfacial self-assembly with the presentation of dopant homopolymer, since the concentration of the latter is known to affect the lateral mobility of the film. The supported polymer films are subsequently surface- modified by microcontact printing using fibronectin (FN), yielding material surfaces which can potentially display independent control over mechanical and adhesive properties. This work demonstrates a new method for the design of materials with the potential to recapitulate the viscous component of the ECM in future in vitro studies.