2 VSV-SRV-2 vaccine protects macaques from detectable infection and B-cell destruction 4 Running Title: Protection of macaques by VSV-SRV vector vaccine 6 Rajeev Gautam 1 , Arun Iyer 3 , Meredith Hunter 1 , Arpita Das 1 , Tessa Williams, Jason 8 Dufor 2 , Cristian Apetrei 1 , K Gus Kousoulas 3 and Preston A Marx 1 * 10 1 Divisions of Microbiology and 2 Division of Veterinary Medicine, Tulane National Primate Research Center, Covington, LA 70433; 3 Division of Biotechnology and 12 Molecular Medicine, LSU School of Veterinary Medicine, Baton Rouge, LA 70803 14 Key Words: SRV, VSV, vaccine, immunity, rhesus macaques, CD20+ B cells, 16 18 Word counts: Abstract: 302 Text: 3947 20 Figures: 5 Tables: 2 22 24  Both authors contributed equally 26 *To whom the correspondence should be addressed. Preston A. Marx, PhD 28 Division of Microbiology, Tulane National Primate Research Center 30 18703 Three Rivers Road, Covington, LA 70433. Tel. (985) 871-6255 32 Fax. (985) 871-6248 Email: pmarx@tulane.edu 34 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Virol. doi:10.1128/JVI.02523-10 JVI Accepts, published online ahead of print on 13 April 2011