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2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim 1 wileyonlinelibrary.com
Co-encapsulation of Biodegradable Nanoparticles with
Silicon Quantum Dots and Quercetin for Monitored
Delivery
Qi Wang, Yongping Bao,* Jayshree Ahire, and Yimin Chao*
DOI: 10.1002/adhm.201200178
Q. Wang, J. Ahire, Dr. Y. Chao
Energy Materials Laboratory
School of Chemistry
University of East Anglia
Norwich, NR4 7TJ, UK
E-mail: y.chao@uea.ac.uk
Dr. Y. Bao
Norwich Medical School
University of East Anglia
Norwich, NR4 7TJ, UK
E-mail: y.bao@uea.ac.uk
Polymer nanoparticles have emerged as a promising new strategy for the
efficient delivery of drugs. They have several advantages when used as drug
carriers, such as high stability, high capacity, improvement of drug bioavaila-
bility, as well as allowing for sustained drug release. Quercetin has therapeutic
potential as an anticancer drug, but has poor solubility and low bioavailability.
In this study it is shown that co-encapsulation of quercetin and fluorescent
Silicon quantum dots (SiQDs) in poly (ethylene glycol)-block-polylactide
(PEG–PLA) nanoparticles can be used for simultaneous in vitro imaging and
to improve the biocompatibility of quercetin. Fluorescent imaging with SiQDs
can provide a new concept to monitor the delivery of anti-cancer drugs. The
nanoparticles are synthesized based on the double emulsion method and are
extensively characterized and assayed for cytotoxicity in vitro. HepG2 cells
are incubated with quercetin and SiQDs dual-loaded PEG–PLA nanoparticles,
resulting in a red fluorescent staining which can be detected with a confocal
microscope. PEG–PLA nanoparticle encapsulated quercetin suppresses human
hepatoma HepG2 cell proliferation more effectively than the free-standing
form. In addition, nanoparticle-encapsulated quercetin significantly inhibits
hydrogen peroxide-induced DNA damage in HepG2 cells. These data show
that nanocapsulated quercetin possesses the potential bioactivity to reduce the
drug dosage frequency, as well as increase patient compliance. The combina-
tion of polymeric nanoparticles and semiconductor quantum dots can allow
monitoring of delivery, improve aqueous solubility, and enhance biocompat-
ibility. Such nanoparticulated systems could shape the future of drug delivery.
nanotechnology for the development of
efficient anticancer drug delivery systems
is one of the most recent advances in bio-
medical science.
[1,4]
The development of
nanovectors, such as nanoparticles (NPs),
can be used to load drugs or imaging
agents which can then be targeted to
tumors.
[1,5]
Nanoparticles are produced
from a wide variety of materials including
carbon, heavy metals, semiconductors,
and polymers, which each have their own
advantages and disadvantages.
[6–8]
Bio-
degradable polymeric nanoparticles have
attracted considerable attention as poten-
tial drug delivery devices.
[9,10]
Most drugs
formulated with organic solvents have
poor solubility and low bioavailability.
[11]
The use of polymeric nanoparticles allows
for the preparation of hydrophobic cancer
medications which have improved bio-
availability.
[12]
Furthermore, the structure
of polymeric nanoparticles can allow them
to encapsulate multiple anticancer drugs,
and visibility enhancers, simultaneously;
while the tunable surface functionality
allows them to conjugate with permeation
enhancers and targeting ligands such as
polyethylene glycol, aptamer, or antibodies
on intended treatment.
[13]
Polyacrylic acid-
terminated SiQDs (PAAc-SiQDs), possess
strong luminescence characteristics, as well as low inherit cyto-
toxicity compared to conventional heavy metal QDs, making
them potentially very useful in biological imaging applica-
tions.
[14,15]
Moreover, the red fluorescence possessed by SiQDs
is not strongly absorbed by cells, rendering them even more
suitable when used as imaging agents.
[14–16]
Polymeric nanoparticles can be synthesised using various
methods tailored to the needs of the application and the type of
drugs to be encapsulated.
[17]
The synthesised nanoparticles are:
stable in blood; non-toxic; biodegradable, which provide con-
trolled release; sub-cellular size; biocompatible with tissue and
cells.
[18]
Polylactide (PLA) is a synthetic biodegradable polymer,
while poly(ethylene glycol) (PEG) possesses good hydrophilicity,
flexibility, resistance to immunological recognition, and biocom-
patibility.
[19]
Consequently PEG–PLA copolymer has great advan-
tages, such as improved hydrophilicity and degradation rate, and
shows a high potential for development in drug delivery.
[19]
1. Introduction
In recent years, nanotechnology has been employed in
cancer diagnosis, detection and treatment.
[1–3]
Utilization of
Adv. Healthcare Mater. 2012,
DOI: 10.1002/adhm.201200178