1 The two variants of OSBP-related protein-1 (ORP1) display different tissue expression patterns, have different intracellular localization, and are functionally distinct Marie Johansson 1 , Virginie Bocher 2 , Markku Lehto 1 , Giulia Chinetti 2 , Esa Kuismanen 3 , Christian Ehnholm 1 , Bart Staels 2 and Vesa M. Olkkonen 1 1 Department of Molecular Medicine, National Public Health Institute, Biomedicum, P.O.Box 104, FIN-00251, Helsinki, Finland; 2 Institut Pasteur de Lille and Faculté de Pharmacie, Université de Lille II-U545 INSERM, 1 rue Calmette, BP 245, 59019 Lille cedex, France; 3 Department of Biosciences, Division of Biochemistry, Viikki Biocenter, Viikinkaari 5, FIN-00014 University of Helsinki, Finland Key words: ankyrin repeat, late endosome, liver X receptor, mRNA expression, oxysterol binding protein, pleckstrin homology domain Running title: Two variants of ORP1 Author for correspondence: Vesa M. Olkkonen, Dept. of Molecular Medicine, National Public Health Institute, Biomedicum, P.O.Box 104, FIN-00251, Helsinki, Finland. Tel. +358-9-4744 8286; Fax +358-9-4744 8960; E-mail vesa.olkkonen@ktl.fi MBC in Press, published on December 7, 2002 as 10.1091/mbc.E02-08-0459