1 “Synthesis, stability and protonation studies of a self-complementary dodecamer containing the modified nucleoside 2’-deoxyzebularine.” Vives, M., Eritja, R., Tauler, R., Marquez, V.E., Gargallo, R. Biopolymers, 73 , 27-43 (2004). Synthesis, stability and protonation studies of a self-complementary dodecamer containing the modified nucleoside 2’-deoxyzebularine M. Vives 1 , R. Eritja 2 , R. Tauler 1 , V. E. Marquez 3 , R. Gargallo 1 * 1 Department of Analytical Chemistry. University of Barcelona. Martí i Franqués, 1 – 11, E-08028 Barcelona, Spain 2 Institut de Biología Molecular de Barcelona-CSIC, Jordi Girona 18-26, E-08034 Barcelona, Spain 3 Laboratory of Medicinal Chemistry, Center for Cancer Research, National Cancer Institut, Frederick, MD 21702, USA. * Correspondence to: R. Gargallo; e-mail: raimon@apolo.qui.ub.es ; fax: +34-934021233 Abbreviations: AcOEt: ethyl acetate, ACN: acetonitrile, bzl: benzoyl, CD: circular dichroism, DCM: dichloromethane, dmf: dimethylaminomethylidene, DMT: 4,4’-dimethoxytrityl, Et 3 N: triethylamine, LCAA-CPG: long chain amino alkyl-controlled pore glass. MCR-ALS: Multivariate Curve Resolution-Alternating Least Squares. OD: optical density measured at 260 nm, TEAA: triethylammonium acetate. Keywords: 2’-deoxyzebularine, spectroscopy, DNA structure, Multivariate Curve Resolution, factor analysis