Mechanisms regulating the large-scale seasonal fluctuations in Alexandrium fundyense populations in the Gulf of Maine: results from a physical-biological model D.J. McGillicuddy, Jr. 1 , D.M. Anderson 1 D.R. Lynch 2 , and D.W. Townsend 3 Manuscript revised and resubmitted to Deep-Sea Research II Ecology and Oceanography of Harmful Algal Blooms in the Gulf of Maine April 27, 2005 1 Woods Hole Oceanographic Institution, Woods Hole, MA 02543, USA. Tel: 508-289-2683 Fax: 508-457-2194 Email: dmcgillicuddy@whoi.edu (Corresponding Author). 2 Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA. 3 School of Marine Sciences, University of Maine, Orono, ME 04469, USA. 1