The Regional Economics Applications Laboratory (REAL) is a cooperative venture between the University of Illinois and the Federal Reserve Bank of Chicago focusing on the development and use of analytical models for urban and regional economic development. The purpose of the Discussion Papers is to circulate intermediate and final results of this research among readers within and outside REAL. The opinions and conclusions expressed in the papers are those of the authors and do not necessarily represent those of the Federal Reserve Bank of Chicago, Federal Reserve Board or Governors of the University of Illinois. All requests and comments should be directed to Geoffrey J.D. Hewings, Director, Regional Economics Application Laboratory, 607 South Mathews, Urbana, IL 61801-3671, Phone (217) 333-4740, Fax (217) 244-9339. Web page: www.uiuc.edu/unit/real PyIO: Input-Output Analysis with Python By Suahasil Nazara, Dong Guo, Geoffrey J.D. Hewings and Chokri Dridi REAL 03-T-23 October 2003