1 Pharmacology of the Urotensin-II Receptor Antagonist ACT-058362: First Demonstration of a Pathophysiological Role of the Urotensin System Martine Clozel, Christoph Binkert, Magdalena Birker-Robaczewska, Céline Boukhadra, Shuang-Shuang Ding, Walter Fischli, Patrick Hess, Boris Mathys, Keith Morrison, Celia Müller, Claus Müller, Oliver Nayler, Changbin Qiu, Markus Rey, Michael W. Scherz, Jörg Velker, Thomas Weller, Jian-Fei Xi, and Patrick Ziltener. Actelion Pharmaceuticals Ltd, Innovation Centre, Allschwil, Switzerland JPET Fast Forward. Published on May 14, 2004 as DOI:10.1124/jpet.104.068320 Copyright 2004 by the American Society for Pharmacology and Experimental Therapeutics.