Accepted Article This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/jcpe.12286 This article is protected by copyright. All rights reserved. Article Type : Animal Experiment Cytokine Gene Expression Profiles during Initiation, Progression and Resolution of Periodontitis J. L. Ebersole 1 , S. Kirakodu 1 , M. J. Novak 1 , A. J. Stromberg 2 , S. Shen 2 , L. Orraca 3 , J. Gonzalez-Martinez 4 , A. Burgos 4 , and O. A. Gonzalez 1* Center for Oral Health Research, College of Dentistry 1 , Department of Statistics, College of Arts and Sciences 2 , University of Kentucky, Lexington, KY; School of Dental Medicine, University of Puerto Rico, San Juan, PR 3 ; and Caribbean Primate Research Center, University of Puerto Rico, Toa Baja, PR 4 . *Corresponding author: Octavio A. Gonzalez, Complete Address: Center for Oral Health Research, College of Dentistry, University of Kentucky, 1095 VA Drive. HSRB 414 Lexington, KY 40536-0305. Phone: (859)-323-0125. Fax number: (859)-257-6566. E-mail: octavio.gonzalez@uky.edu Running title: T helper cytokines in periodontitis KEY WORDS: Periodontitis, T helper cytokines, gingival tissue, adaptive immunity, Matrix metalloproteinase, RANKL. SOURCES OF FUNDING: This work was supported by National Institute of Health grants P20GM103538 and UL1TR000117. DISCLOSURE The authors report no conflicts of interest related to this study.