Journal of Agricultural and Veterinary Sciences Qassim University, Vol. 4, No. 2, pp. 109-123 (July 2011/Rajab 1432H) 109 Monitoring of Tetracycline Residues in Table Eggs Collected From Qassim Region, KSA Naser A. Al-Wabel Department of Veterinary Medicine, College of Agriculture & Veterinary Medicine, Qassim University, Buraidah 51452, P.O. Box 6622, Saudi Arabia (Received 15/4/2011, accepted for publication on 23/6/2011) Abstract. The present study was designed to monitor tetracycline residues in table eggs collected from different regions located in Al-Qassim region from January 2006 to October 2006 using HPLC with UV detection and compare them with internationally acceptable maximum residue limits (MRLs) and assessing proper implementation of the proper withdrawal times. HPLC analysis showed that geographical and seasonal differences in OTC levels. The number of positive samples found in all regions during October 2006 were higher (n= 27) than that collected during January (n= 21), July (n= 19) and April (n= 17). Moreover, the percentages of total occurrence of the positive samples collected from Eion Al-Gawa (57.5) was higher than that in Al-Moznab (55), Buraidah (47.5), Al-Shamasia (27.5) and Oneiza (22.5) with 14, 12, 8, 5 and 5 samples exceeding MRLs, respectively. The results of present investigation indicate that there is widespread misuse of tetracycline by egg layer chicken farms in Al-Qassim region reflecting a general lack of compliance with the recommended practices regarding the use of antimicrobial agents. These findings pointed to the following recommendations: the need for a monitoring program for tetracycline residues in table eggs in Al-Qassim region at the national level to protect consumers health. Keywords: Tetracycline Residues, table eggs, Qassim, withdrawal period Corresponding author. Tel. +96663800050 ; Fax. +96663801360 E-mail address: naseralwabel@yahoo.com