Review Article International Journal of Pharmaceutical Chemistry and Analysis, January-March, 2016;3(1):43-48 43 Chemometrics and its Applications in UV Spectrophotometry Parixit Rohitbhai Prajapati 1,* , Deepika Natu Rathod 2 , Vishalkumar Shashikant Modi 3 , Tarashankar Basuri 4 1,3,4 Assistant Professor, 2 Research Scholar, Dept. of Quality Assurance Techniques SSR College of Pharmacy, Silvassa, U.T. of Dadra & Nagar Haveli-396230 *Corresponding Author Email: parixitprajapati@gmail.com Abstract Chemometrics is the major developed branch which is widely employed in various pharmaceutical fields. Basically it is combination of chemical data along with mathematical and statistical treatment of the data using various mathematical models and software’s. The developmental of various computational complexities along with the widespread growth of spectroscopy has used chemometrics for better results of the data obtained in spectroscopy. The review will highlight introduction to chemometrics, various chemometrics regression analysis techniques and applicability of chemometrics in UV visible spectrophotometry along with some application. Keywords: Chemometrics, Classical Least Squares, Inverse Least Squares, Multi-linear regression, Principal Component Regression, Partial Least Squares Regression, UV Spectrophotometry. Access this article online Quick Response Code: Website: www.innovativepublication.com DOI: 10.5958/2394-2797.2016.00005.8 Introduction Chemometrics can chiefly be described as the interaction of certainmathematical and statistical methods to chemical analysis and problems. Field of chemometrics started to grow around seventies and has widely influenced area of chemistry along with analytical chemistry. The science of chemometrics has developed because of changes in enormous data which is obtained in chemistry along with the evolution of new analytical techniques and technologies along with computer technology. The development of computer technology has tremendously caused the wide growth of chemometrics since majority of multivariate methods utilized in chemometrics depend upon the ability and capability of computers to perform large calculations obtained by the chemometrics methods. In analytical chemistry chemometrics techniques has its applications in spectroscopy like UV-Visible spectrophotometry,NIR spectroscopy, fluorescence spectroscopy, chromate- graphy like Liquid Chromatography and also various other aspects of analytical chemistry like flow-injection analysis in pharmaceutical preparations. The connection and usage of chemometrics and spectroscopy is as shown below (1) : Fig. 1: Illustration of why spectroscopy and chemometrics work well in conjugation.