45 years or over who lived in Chuncheon city. We devided into two group- s(low and high PWV) according to median value and into three tertiles(tertile 1, 2, 3) of serum adiponectin concentration. Multiple logistic regression was used to evaluated association of adiponectin concentration levels and baPWV, adjusting for covariates such as age, gender, smoking, alcohol, regular exercise and laboratory data including lipid profiles. Results: Table shows odds ratios and 95% confidence intervals on the risk of high baPWV by sex-specific tertile of serum adiponectin. Higher level adiponectin concentration were associated with low baPWVs after adjust- ment for other covariates. Conclusions: Higher adiponectin is independently associated with low brachial-ankle pulse wave velocity among local residents aged 45 or over. Limitations: However, this findings based on cross-sectional analyses can not directly prove causal relationship between adiponectin and baPWV. PP.12.458 METHYLGLYOXAL AND SUBCLINICAL INFLAMMATION IN THE HYPERTENSIVE PATIENTS E. Oschepkova, V. Dmitriev, O. Polovitkina, V. Titov. Russian Cardiology Research Complex, Moscow, Russia Objective: Recent studies showed association of elevated methylglyoxal (MG) levels with increased reactive oxygen species (ROS) and advanced glycation end products (AGEs) in hypertensive animals that indicate what MG might contribute to the development of hypertension. The aim of our study was to investigate association of MG with subclinical inflammation markers in the essential hypertensive patients (pts). Design and Method: 70 EH pts (53 M, 17 F) grade 1 or 2, without diabetes mellitus, av.age 44,9  1,6 years, without antyhypertensive therapy for 2 weeks before study. Patients with acute inflammatory diseases, not earlier than 2 months were included in study. MG level was defined by liquid chromatography (normal level is 12,1–29,8 nmol/ml). High-sensitivity C- reactive protein (CRP) was defined by a turbidimetry method, Serum uric acid (SUA) was defined by a UF method on the uricase selective analyzer. Total antioxidant activity (AOA) blood serum was determined by liquid chromatography with electrochemical detection. 24 hour blood pressure monitoring (24-h BPM) was carried out by Meditech ABPM-04 (Hungary). The statistical analysis was carried out by nonparametric methods of Mann- Whitney with STATISTICA 6. The data is presented as M  m. Results: In the whole group of EH pts MG levels were 31,2  2,3 nmol/ml. The average levels of CRP, SUA and total AOA were considerably higher in the increase MG hypertensives (I group) compared to normal MG hyper- tensives (group II). 24-h SBP and DBP levels was not difference (Table) Table Conclusion: Our study showed significant association Methylglyoxal and subclinical inflammation markers in the hypertensive patients. Possibly, that processes may cause development of hypertension in high Methylglyoxal group. PP.12.459 COMPARISON OF PLASMA CHROMOGRANIN A BETWEEN PATIENTS WITH ESSENTIAL HYPERTENSION, HEALTHY SUBJECTS AND PATIENTS WITH PHEOCHROMOCYTOMA V. Vasilev, J. Matrozova, A. Elenkova, G. Kirilov, S. Zacharieva. Clinical Centre of Endocrinology and Gerontology, Sofia, Bulgaria Chromogranin A (ChrA) is an acidic soluble protein that plays an important role in formation of dense core vesicles of neuroendocrine cells. Apart from being useful in the diagnosis of multiple endocrine tumours, such as pheochromocytoma, it is increasingly being recognized as an important factor in cardiovascular disease and essential hypertension (EH). A number of studies have demonstrated the link between increased sympathoadrenal activity and hypertension, showing increased ChrA levels in patients with EH, while others have found no evidence for direct effect of ChrA in modulating blood pressure. Aim: The aim of this study was to compare ChrA levels between patients with EH, healthy controls (HC) and patients with pheochromocytoma. Patients and Metbods: The study population consisted of 30 patients with EH, 12 patients with pheochromocytoma and 39 HC. Chromogranin (nmol/l) was measured in peripheral blood by radioimmunoassay. Results: Patients with pheochromocytoma had higher levels of ChrA than HC and hypertensive patients (11.05 vs. 4.15 vs. 5.03 nmol/l, respectively, p < 0.001) but there was no statistically significant difference between HC controls and patients with EH (p ¼ 0.123). No difference was found in age and sex distribution between the three groups (p ¼ 0.853 and p ¼ 0.429, respectively). Conclusions: Patients with pheochoromocytoma exhibit highly elevated levels of ChrA compared to both groups, as expected. However, our findings do not confirm previous reports as we observed no significant difference in ChrA levels between essential hypertensives and NC and a possible expla- nation could be the influence of antihypertensive therapy in our hyperten- sive patients. On the other hand it has been shown that the majority of antihypertensive drugs do not alter ChrA levels, therefore our results require further investigation. PP.12.460 BNP MEASUREMENT PRE- AND POST-NONCARDIAC SURGERY AS PROGNOSTIC FACTOR OF CARDIOVASCULAR EVENTS IN HYPERTENSIVE PATIENTS V. Talucci 1 , L. Magrini 1 , N. Petrucciani 2 , A. Scarinci 2 , P. Mercantini 2 , C. Spallotta 1 , A. Mastrantuono 1 , S. Di Somma 1 , V. Ziparo 2 . 1 A.O.S.Andrea- Emergency Dept.-University La Sapienza, Rome, Italy, 2 A.O.S.Andrea-Surgery Dept. 1-University La Sapienza, Rome, Italy Introduction: Cardiovascular events in patients undergoing non-cardiac surgery are higher than other complications; they are associated with high levels of morbidity and mortality and represent the first cause of death e188 Journal of Hypertension Vol 28, e-Supplement A, June 2010