793 Trasplante hepático en Chile: Aspectos generales, indicaciones y contraindicaciones (Documento de consenso) Juan Hepp 1 , Rodrigo Zapata 1,6 , Erwin Buckel 2,5,6 , Jorge M artínez 3 , Mario Uribe 2,5,6 , Juan Carlos Díaz 4 , Mario Ferrario 2,5,6 , Edgar Sanhueza 1 , Rosa M aría Pérez 3 , Bessie H unter 2,5 , Gloria Ríos 1 , Roberto Humeres 1 , Jaime Poniachik 4 , D anny O ksenberg 4 , M arco Arrese 3 . General considerations, indications and contraindications for liver transplantation in Chile. A multicenter consensus development document Liver transplantation is an excellent therapeutic option for terminal liver disease. During the last decades the results of liver transplantation have improved significantly with a patient survival rate of nearly 90% at one year and 80% at 5 years of follow-up. The main indications for liver transplantation include: end-stage liver disease associated to cirrhosis, acute liver failure, and hepatic tumors (mainly hepatocarcinoma). The absolute contraindications for a transplant are less frequent than in the past, and include: severe co-morbidity (cardiac or pulmonary), sepsis, advanced HIV disease and extra-hepatic malignancy. This document presents a Consensus of the main groups performing liver transplantation in Chile, about its indications and contraindications. It also reviews general aspects of liver transplantation, including the selection and referral of liver transplant candidates, allocation of organs and the evaluation of severity of liver disease (Rev Méd Chile 2008; 136: 793-804). ( Key words: Consensus; Fibrosis; Liver failure, acute; Liver transplantation) Recibido el 25 de septiembre, 2007. Aceptado el 13 de mayo, 2008. 1 Unidad de Trasplante Hepático de Clínica Alemana de Santiago. 2 Unidad de Trasplante Hepático de Clínica Las Condes. 3 Unidad de Trasplante Hepático de la Universidad Católi- ca de Chile. 4 Unidad de Trasplante Hepático del Hospital José Joaquín Aguirre, Universidad de Chile. 5 Unidad de Trasplante Hepático, Hospital Luis Calvo Mackenna. 6 Unidad de Trasplante Hepático del Hospital del Salvador. Correspondencia a : Dr. Juan Hepp K. Clínica Alemana. Vitacura 5951. Santiago, Chile. Fax: 2101400. E mail: jhepp@alemana.cl Rev Méd Chile 2008; 136: 793-804 A R T Í C U L O E S P E C I A L