Synthesis, spectral characterization, antibacterial and antitumor studies of some diorganotin(IV) complexes derived from 2-phenylmonomethylglutarate Wajid Rehman a,⇑ , Amin Badshah b , Fazal Rahim a , Musa Kaleem Baloch c , Hameed Ullah a , Obaid-Ur-Rahman Abid a , Mohsan Nawaz a , Isfahan Tauseef d a Department of Chemistry, Hazara University, Mansehra, Pakistan b Department of Chemistry Quaid-e-Azam University, Islamabad, Pakistan c Department of Chemistry, University of Sargodha, Bhakkar Campus, Bhakkar, Pakistan d Department of Microbiology, Hazara University, Mansehra, Pakistan article info Article history: Received 1 May 2014 Received in revised form 10 July 2014 Accepted 6 August 2014 Available online 13 August 2014 SI: Antitumor Active Organotin Compounds Keywords: 2-Phenylmonomethylglutarate Antitumor Antibacterial Organotin(IV) abstract A novel series of diorganotin(IV) complexes of the type R 2 SnL 2 (R = Me, Et, Bu, Ph Bz and L = 2-phenylm- onomethylglutarate) has been reported herein. The synthesized compounds has been characterized by elemental analysis and their solid state configuration has been determined by various spectroscopic (IR, 1 H, 13 C, 119 Sn NMR, 119m Sn Mössbauer) techniques. The results obtained are in full agreement with the proposed 2:1 stoichiometry. The title complexes have been screened against various Gram positive and Gram negative bacteria and human cell line KB, the results obtained showed that the diphenyltin(IV) complex exhibited excellent activity against all types of bacteria, while diethyltin(IV) complex was found to have promising antitumor activity. Ó 2014 Elsevier B.V. All rights reserved. 1. Introduction The chemistry of organotin(IV) complexes has observed a dra- matic rise during the last few eras. They have been practiced for their in vitro activity against a large variety of tumor lines and found to be as effective as conventional heavy metal antitumor drugs such as Cisplatin [1]. In addition to the aforementioned uses, organotin compounds are also important in prospect of their broad structural diversity. This feature has been attracting the interest of a number of scientists and an enormous amount of structural types have been uncovered [2,3]. There has been considerable interest in the chemistry of penta- and hexacoordinated organotin(IV) com- plexes derived from various organic ligands due to their structural and stereochemical properties, in obvious contrast to the well doc- umented chemistry of organotin(IV) complexes [4–6]. Organo- tin(IV) complexes are put to use in various fields and exhibit potential biological applications such as bactericidal, insecticidal, fungicidal and antitumor activities. Organotin compounds are now the active components in a number of biocidal formulations, finding applications in such diverse areas as fungicides, miticides, molluscicides, marine antifouling paints, surface disinfectants and wood preservatives [7–9]. In order to magnify the scope of investigations on the coordination behavior of various donor ligands towards organotins, we carried out the investigations and established their bioactivities [10–15]. As an extension of this research field, we are now interested in the development of the chemistry of some novel organotin compounds obtained by the interaction of a number of diorganotin(IV) halides with the 2-phenylmonomethyl glutarate. 2. Experimental All the diorganotin(IV) compounds except dibenzyltin dichlo- ride were purchased from Merck and were used as such. Dibenzyl- tin dichloride was synthesized through a known method [16]. The solvents used were dried before use according to the prescribed method [17]. Melting point was measured on a Reichert thermom- eter of F.G. Bode Co. Austria. IR spectra were obtained in KBr using Perkin Elmer FT IR –1605 spectrophotometer. An elemental analy- sis was carried out on a Yanaco MT-3 high-speed CHN analyzer with an antipyrine as a reference compound. The amount of tin http://dx.doi.org/10.1016/j.ica.2014.08.006 0020-1693/Ó 2014 Elsevier B.V. All rights reserved. ⇑ Corresponding author. Tel.: +92 997 414136; fax: +92 997 530046. E-mail address: sono_waj@yahoo.com (W. Rehman). Inorganica Chimica Acta 423 (2014) 177–182 Contents lists available at ScienceDirect Inorganica Chimica Acta journal homepage: www.elsevier.com/locate/ica