Type I IFN affects early and late immunity to HMPV Hastings et al Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. Running Title: Type I IFN affects early and late immunity to HMPV Andrew K. Hastings * , John J. Erickson * , Jennifer E. Schuster † , Kelli L. Boyd*, Sharon J. Tollefson † , Monika Johnson † , Pavlo Gilchuk * , Sebastian Joyce * , John V. Williams *,†,‡ Departments of * Pathology, Microbiology & Immunology and † Pediatrics, Vanderbilt University School of Medicine, Nashville, TN 37232 Funding Sources: ‡ Corresponding Author: John V. Williams 1161 21 st Avenue South, D-7235 MCN Nashville, TN 37232-2581 Telephone: 615-936-2186 Facsimile: 615-343-9723 Electronic: john.williams@vanderbilt.edu Abstract word count: 218/250 Manuscript character count: 5339 JVI Accepted Manuscript Posted Online 4 February 2015 J. Virol. doi:10.1128/JVI.03275-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved.