Monday AM 1 OPENING SESSION Main Hall 07:45  08:20 07:45 Welcome and Medal Presentations Michael E. Moseley, President EIGHTH ANNUAL LAUTERBUR LECTURE Main Hall 08:20  09:00 Chairs: Rolf Gruetter and Seiji Ogawa 08:20 From Immune Suppression to Mad Cow Disease  In Vitro NMR Spectroscopy with the Molecules of Life Kurt Wüthrich 1 ETH, Zürich, Switzerland PLENARY LECTURES: MR Impact in Metabolomics and Proteomics Main Hall 9:00 - 10:15 Chair: SebastiÆn CerdÆn 9:00 1. From Genome to Metabolome Kevin Brindle 1 1 University of Cambridge, Cambridge, UK With the completion of a growing number of genome sequences attention is now turning to functional genomics, the elucidation of gene function from studies of the effects of gene modification on cellular phenotype. Magnetic resonance has an important role to play in this enterprise, from imaging changes in tissue morphology to spectroscopic measurements of changes in tissue biochemistry. This lecture will deal with MRS analysis of the small-molecule metabolite complement of the cell, the metabolome, and how this might be used, in conjunction with gene modification, to deduce gene function. 9:25 2. The Tumor Metabolome by MRS: Implications for Medical Diagnosis John R. Griffiths 1 1 St. George’s Hospital Medical School, London, England, UK Metabolomics, the youngest of the -omics sciences, is concerned with the totality of small molecules in an organism. NMR is attractive for investigating metabolic profiles, sub-sets of the metabolome, with minimal sample preparation. Metabolic profile studies are beginning on the effects of gene knockouts, inhibitions or overexpressions in cancer cells in culture as well as in experimental tumors. It is also possible to combine these data with conventional in vivo MRS studies of cancer in patients. Metabolomics can be used in drug discovery programs to indicate novel drug targets and to detect mechanisms of action or unwanted cellular side-effects. 9:50 3. MR-Based Metabonomic Approaches in Toxicology, Disease Diagnosis and Global Systems Biology Jeremy K. Nicholson 1 1 Imperial College Faculty of Medicine, London, England, UK Metabonomics involves the use of MRS and other spectroscopic tools to enable multivariate profiling of the integrated metabolic responses of complex systems to patho-physiological stress and disease. High frequency MRS can be applied to characterize a wide range of metabolites in biological fluids as spectra are changed characteristically in different toxicity or disease conditions. Pattern recognition analysis can give direct diagnostic information and aid the detection of novel biomarkers of disease. Novel methods of metabolic screening using probabilistic modelling approaches can now enable rapid toxicological and clinical assessments based on MRS of biofluids.