Asthma phenotypes in Turkey: a multicenter cross-sectional study in adult asthmatics; PHENOTURK study Fusun Yildiz 1 , Dilsad Mungan 2 , Bilun Gemicioglu 3 , Arzu Yorgancioglu 4 , Berna Dursun 5 , Ferda Oner Erkekol 6 , Candan Ogus 7 , Haluk Turktas 8 , Gunhan Bogatekin 9 , Fusun Topcu 10 , Figen Deveci 11 , Hasan Bayram 12 , Meltem Tor 13 and A. Fuat Kalyoncu 14 1 Pulmonary Diseases Department, Kocaeli University School of Medicine, Kocaeli, Turkey 2 Department of Allergy, Ankara University School of Medicine, Ankara, Turkey 3 Pulmonary Diseases Department, Istanbul University Cerrahpasa School of Medicine, Istanbul, Turkey 4 Pulmonary Diseases Department, Celal Bayar University School of Medicine, Manisa, Turkey 5 Pulmonary Diseases Department, Recep Tayyip Erdo gan University School of Medicine, Rize, Turkey 6 Department of Allergy, Ataturk Chest Diseases and Thoracic Surgery Research Hospital, Ankara, Turkey 7 Pulmonary Diseases Department, Akdeniz University School of Medicine, Antalya, Turkey 8 Pulmonary Diseases Department, Gazi University School of Medicine, Ankara, Turkey 9 Diyarbakir State Hospital, Diyarbakir, Turkey 10 Pulmonary Diseases Department, Dicle University School of Medicine, Diyarbakir, Turkey 11 Pulmonary Diseases Department, Firat University School of Medicine, Elazig, Turkey 12 Pulmonary Diseases Department, Gaziantep University School of Medicine, Gaziantep, Turkey 13 Pulmonary Diseases Department, Bulent Ecevit University School of Medicine, Zonguldak, Turkey 14 Department of Allergy, Hacettepe University School of Medicine, Ankara, Turkey Key words allergy 2 asthma 2 control level 2 disease onset 2 obesity 2 phenotypes 2 severity Correspondence Fusun Yildiz, MD, Kocaeli University School of Medicine, Division of Chest Diseases, Umuttepe Merkez Yerleskesi, 41380 Kocaeli, Turkey Tel: 190 262 303 7513 Fax: 190 262 303 7003 email: fusun.yildiz@gmail.com Received: 19 February 2015 Accepted: 14 May 2015 DOI:10.1111/crj.12326 Authorship and contributorship Fusun Yildiz is responsible for collection of data and writing of manuscript. Dilsad Mungan, Bilun Gemicioglu and A. Fuat Kalyoncu are responsible for editing of manuscript. Arzu Yorgancioglu, Berna Dursun, Ferda Oner Erkekol, Candan Ogus, Haluk Turktas, Gunhan Bogatekin, Fusun Topcu, Figen Deveci, Hasan Bayram and Meltem Tor are also responsible for the collection of data. Ethics Written informed consent was obtained from each subject following a detailed explanation of the objectives and protocol of the study, which was conducted in accordance with the ethical principles stated in the ‘Declaration of Helsinki’ and approved by the institutional ethics committee. Abstract Background and Aims: To evaluate asthma phenotypes in patients with asthma from different regions of Turkey. Methods: A total of 1400 adult asthmatic patients (mean (SD) age: 44.0 (13.9) years, 75% females) from 14 centers across Turkey were included in this study and a standard questionnaire was applied between the time period of February 2011–Jan- uary 2012. Results: The disease onset  40 years of age was higher percentage in obese vs. nor- mal/overweight patients and nonallergic vs. allergic patients (P < 0.01). The percent- age of patients who had FEV1 values over 80% was higher in allergic than nonallergic and normal/overweight than obese patients (P < 0.01). Uncontrolled asthmatics have more severe disease (P < 0.01). There were more frequent hospital admissions in nonallergic and uncontrolled asthmatics (P < 0.01). Chronic rhino- sinusitis was the leading comorbid disorder in normal/overweight and allergic asthma, while gastroesophageal reflux disorder was more frequent in nonallergic and uncontrolled asthma (P < 0.01). Asthma control rate was the highest (39.0%) in patients from Marmara region among all geographical regions (P < 0.05). Conclusion: In conclusion, our findings revealed existence of clinical/trigger related phenotypes based on BMI, allergic status, control level and geographical region with more frequent respiratory dysfunction and/or adverse health outcomes in uncontrolled, obese and nonallergic phenotypes. Please cite this paper as: Yildiz F, Mungan D, Gemicioglu B, Yorgancioglu A, Dursun B, Oner Erkekol F, Ogus C, Turktas H, Bogatekin G, Topcu F, Deveci F, Bayram H, Tor M and Fuat Kalyoncu A. Asthma phenotypes in Turkey: a multicen- ter cross-sectional study in adult asthmatics; PHENOTURK study. Clin Respir J 2015; 00: 000–000. DOI:10.1111/crj.12326 Conflict of interest The authors declare that they have no conflict of interest related to this study. The Clinical Respiratory Journal (2015) • ISSN 1752-6981 V C 2015 John Wiley & Sons Ltd 1 The Clinical Respiratory Journal ORIGINAL ARTICLE