UNCORRECTED PROOF 1 Q1 Clinical trial management of participant recruitment, 2 enrollment, engagement, and retention in the SMART study 3 using a Marketing and Information Technology 4 (MARKIT) model 5 Q2 Anjali Gupta a,c,e, ⁎ Q3 , Karen J. Calfas b , Simon J. Marshall a,b , Thomas N. Robinson g , Cheryl L. Rock b , 6 Jeannie S. Huang a,d , Melanie Epstein-Corbin a , Christina Servetas a , Michael Donohue a , 7 Gregory J. Norman b , Fred Raab a , Gina Merchant a , James H. Fowler a,f , William G. Griswold a , 8 B.J. Fogg h , Kevin Patrick a,b 9 a Q4 Center for Wireless and Population Health Systems, Calit2, University of California, San Diego, La Jolla, CA 92093, United States 10 b Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, United States 11 c Rady Children's Hospital, San Diego, CA 92123, United States 12 d Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093, United States 13 e Department of Computer Science and Engineering, University of California, San Diego, CA 92093, United States 14 f Medical Genetics Division and Political Science Department, University of California, San Diego, CA 92093, United States 15 g Stanford Solutions Science Lab, Division of General Pediatrics, Department of Pediatrics and Stanford Prevention Research Center, Stanford University School of Medicine, 16 Stanford, CA 94305, United States 17 h Behavior Design Lab, Stanford University School of Medicine, Stanford, CA 94305, United States 18 article info 20 abstract 21 Article history: 22 Received 19 January 2015 23 Received in revised form 31 March 2015 24 Accepted 1 April 2015 25 Available online xxxx 26 Advances in information technology and near ubiquity of the Internet have spawned novel modes 27 of communication and unprecedented insights into human behavior via the digital footprint. 28 Health behavior randomized controlled trials (RCTs), especially technology-based, can leverage 29 these advances to improve the overall clinical trials management process and benefit from 30 improvements at every stage, from recruitment and enrollment to engagement and retention. In 31 this paper, we report the results for recruitment and retention of participants in the SMART study 32 and introduce a new model for clinical trials management that is a result of interdisciplinary team 33 science. The MARKIT model brings together best practices from information technology, marketing, 34 and clinical research into a single framework to maximize efforts for recruitment, enrollment, 35 engagement, and retention of participants into a RCT. These practices may have contributed to the 36 study's on-time recruitment that was within budget, 86% retention at 24 months, and a minimum of 37 57% engagement with the intervention over the 2-year RCT. Use of technology in combination with 38 marketing practices may enable investigators to reach a larger and more diverse community of 39 participants to take part in technology-based clinical trials, help maximize limited resources, and 40 lead to more cost-effective and efficient clinical trial management of study participants as modes of 41 communication evolve among the target population of participants. 42 © 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC- 43 ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 44 Keywords: 45 Clinical trial management 46 Marketing 47 Social media 48 Technology 49 Intervention 50 Behavior Contemporary Clinical Trials xxx (2015) xxx–xxx ⁎ Corresponding author at: Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, United States. E-mail address: agupta@sanfordburnham.org (A. Gupta). CONCLI-01173; No of Pages 11 http://dx.doi.org/10.1016/j.cct.2015.04.002 1551-7144/© 2015 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Contents lists available at ScienceDirect Contemporary Clinical Trials journal homepage: www.elsevier.com/locate/conclintrial Please cite this article as: Gupta A, et al, Clinical trial management of participant recruitment, enrollment, engagement, and retention in the SMART study using a Marketing a..., Contemp Clin Trials (2015), http://dx.doi.org/10.1016/j.cct.2015.04.002