The Journal of Applied Research • Vol. 4, No. 1, 2004 173 required dialysis post-transplantation respectively. Cold ischemic times between groups were similar (P>0.2). Poor urine flow post-ureteric anastomo- sis was more frequent in Group B (4 versus 12). Eighteen of 19 patients who had passed less than 1 liter of urine in the first 24 hours developed DGF. Serum creatinine at 3, 6, and 12 months post-transplantation were not signifi- cantly different between the groups (P=0.15, 0.1, and 0.6). Patients with DGF irrespective of frusemide adminis- tration had significantly higher creati- nine values throughout (P<0.01). All recipients had negative cross- matches and 60% and 71% had 3 HLA matches. Mean donor ages were similar between groups (P=0.34). Underlying hypertension was more common in the donors for Group A (35% versus 19%) but terminal serum creatinines were similar (86.5±.7 versus 88.3±4.0 μmol/L). Atheroma in the donor renal artery or attached aortic patch was present in 37% of Group A patients and 31% of Group B cases. In this limited study, frusemide Early Postoperative Urine Flow Predicts Delayed Graft Function Irrespective of Diuretic Use Sunil Bhandari, PhD, FRCP *† David Eisinger, MD, FRACS ‡ Josette Eris, PhD, FRACP * *Department of Transplant Medicine, Statewide Renal Services, Royal Prince Alfred Hospital, Sydney, Australia † Department of Renal Medicine,Hull and East Yorkshire Hospitals NHS Trust Hull Royal Infirmary, Kingston upon Hull, East Yorkshire, UK ‡ Department of Urology, Statewide Renal Services, Royal Prince Alfred Hospital, Camperdown, Sydney, Australia KEY WORDS: cadaveric,delayed function, diuretic, frusemide, renal, transplantation ABSTRACT Delayed graft function (DGF), a mani- festation of ischemic/reperfusion injury, is detrimental to allograft survival. Urine flow may predict development of delayed graft function. Intraoperative frusemide during cadaveric renal trans- plantation may reduce DGF.We per- formed a retrospective analysis of consecutive renal transplants over a 3- year period. Patients received frusemide or no diuretic intraoperatively. Allograft function postoperatively was determined by a 10% fall in serum creatinine in the first 24 hours or need for dialysis in the first week. Of the 99 patients in the study group, 57 patients received frusemide (Group A) and 42 patients received no diuretic (Group B). Thirty % of Group A patients and 31% of Group B patients had DGF. Fourteen patients in Group A and 12 patients in Group B