Signatures of Co-translational Folding Rhodri Saunders 1,â , Martin Mann 2,â and Charlotte M. Deane 1 1 Oxford University, Department of Statistics, 1 South Parks Road, Oxford, OX1 3TG, UK 2 University of Freiburg, Bioinformatics, Georges-K¨ ohler-Allee 106, 79110 Freiburg, Germany â These authors contributed equally to this work. Keywords: Co-translational folding, Protein structure, HP model, SCOP do- mains, Vectorial folding Correspondence: Charlotte Deane, Oxford University, Department of Statistics, 1 South Parks Road, Oxford, OX1 3TG, UK Email: deane@stats.ox.ac.uk, Fax: +44 1865 272595, Phone: +44 1865 281301 Abbreviations: CT - Co-Translational; HP - Hydrophobic-Polar; MCR - Mean Central Residue; MoI - Moment of Inertia; NCcen - relative N- and C-terminal centrality; PHI - Possible Hydrophobic Interactions; SSE - Secondary Structure Element; UGEM - Unique Global Energy Minimum 1