19th World Congress on Ultrasound in Obstetrics and Gynecology Oral poster abstracts OP23.08 Perinatal outcome does not differ in IUGR fetuses born from normotensive women versus IUGR from preeclamptic women: a multicenter study E. Cosmi 1 , C. Saccardi 1 , V. Berghella 2 , E. Ferrazzi 3 , A. A. Baschat 4 1 Obstetrics and Gynecology, University of Padua, Padua, Italy; 2 Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA, USA; 3 Obstetrics and Gynecology, University of Milan, Milan, Italy; 4 Obstetrics and Gynecology, University of Maryland, MD, USA Objective: To assess the difference in perinatal outcome in IUGR fetuses from normotensive women versus IUGR because maternal preeclampsia Methods: A multicenter observational study on IUGR fetuses delivered < 32 weeks for fetal indications and without a significative difference in gestational age and weight at birth IUGR because isolated placental insufficiency and maternal preeclampsia. Perinatal outcome, pH and base excess at birth were compared. Neonatal outcome was correlated to Doppler velocimetry alteration of the fetus, divided into early (umbilical artery and middle cerebral artery alterations) and late Doppler alterations (reversed flow in the umbilical artery and ductus venosus abnormality). Results: The study group consisted of 150 IUGR fetuses because of isolated placental insufficiency and 98 because maternal preeclampsia. Mean gestational age at delivery was 29.4 ± 1.7 weeks and mean birth weight 895.7 ± 224.6 gr. in the first group; 29.4 ± 1.7 weeks and 929.6 ± 182.7 gr. in the second group. There were no significative difference in morbidity and mortality rate among the groups. Considering separately, all the variables but preeclampsia appeared significant in determining neonatal morbidity and mortality. Late Doppler alterations and gestational age were the most relevant variables determining neonatal morbidity (p = 0.005) and mortality (p = 0.003) considering fetus before birth. Considering the newborn the most important variable determining neonatal morbidity was birth weight (p = 0.001) and for neonatal mortality were late Doppler alterations (p = 0.038), neonatal weight (p = 0.002), low pH (p = 0.001) and BE (p = 0.005) Conclusions: The present study highlights that IUGR fetuses because of isolated placental insufficiency or maternal preeclampsia did not differ in perinatal outcome addressing that late Doppler alterations and weight at birth are predictors for adverse outcome. OP23.09 Contribution of fetal growth restriction to unexplained stillbirth J. J. Jaramillo , A. Mendez, O. Tamayo, E. Gratacos, F. Figueras Maternal Fetal Medicine, Hospital Clinic, Universidad de Barcelona, Barcelona, Spain Objective: To estimate the contribution of fetal growth restriction (FGR) to unexplained stillbirth in third trimester of pregnancy. Materials and methods: A case-control study was designed, including as cases 29 consecutive stillbirths attended in our hospital between 2004 to 2008 and originated within our catchment area. Inclusion criteria were: 1. Singleton pregnancy; 2. Gestational age beyond 24.0 weeks (corrected by first-trimester US); and, 3. A negative work- up including post-mortem examination, maternal thrombophilia and diabetes, maternal and fetal infections, feto-maternal hemorrhage and karyotiping. Controls were individually matched 2 : 1 (n = 58) with cases by gestational age at delivery (+1); ethnicity (Caucasian vs. non-Caucasian); smoking (non-smoking; 1–9; 10+); body mass index (< 25, 25–29.9, 30+); and parity (primipara versus non- primipara). Controls were selected as the following two women immediately delivering after each case and fulfilling the matching criteria. FGR was defined as a birth weight below the 10 th customized centile according to local standards. Data were retrospectively retrieved from the medical records. Odds ratios (OR) and their 95% confidence intervals (CI) for stillbirth and the population attributable fraction (etiological fraction) were calculated for matched data. Results: FGR was present in 15/29 (51%) and 9/58 (15%) of the cases and controls, respectively (Chi-squared test < 0.001). The OR for unexplained stillbirth of FGR was 8.0 (95%CI 2,3–28,1). The population attributable fraction was 39.7% (95% CI 20.9–62). Conclusions: FGR is a major contributor to unexplained stillbirth being etiologically responsible for a third of the cases occurring in the population. OP23.10 Correlation between Hadlock growth percentile and perinatal outcome in IUGR (intrauterine growth restriction and SGA (small gestational age) babies L. Pallar` es Porta , L. Almeida Toledano, L. Alu´ e Ponti, L. L ´ opez Chardi, M. Reig Jorge, M. G ´ omez-Roig Gynecology and Obstetrics, Hospital Sant Joan de D´ eu (Barcelona), Martorell, Spain Objective: To compare perinatal outcome of IUGR and SGA babies. Material and methods: This is a longitudinal prospective study, carried out in Sant Joan de D´ eu Hospital in Barcelona, with an annual volume of 4535 deliveries and 11 364 ultrasounds. The study lasted 12 months (from January 2008 until December 2008) and includes 160 cases of IUGR or SGA. This hospital is a reference center for this kind of fetal pathology. We used the Hadlock’s reference curves to estimate the fetal weight. We used the Catalan reference curves for delivery weight. Exclusion criteria: pregnancy or birth not being under control in our hospital, multiple pregnancy. Results: Significant differences were observed between IUGR and SGA in non-reassuring fetal heart rate status (19.4% 3.8%)(p < 0.001), gestational age at delivery (35 vs 38 weeks)(p < 0.001), Cesarean delivery (both elective and emergent, 25.6% vs 14.4%)(p > 0.001) and neonatal admission (20.6 vs 13.8%)(p = 0.003), which main causes were prematurity, infection risk and low weight. Non significant differences were observed in maternal age, APGAR score, AFI (amniotic fluid index), baby sex and bad previous obstetric outcome. Conclusions: Perinatal outcome is better in SGA than in IUGR, so it is necessary to establish serial controls closer in time for IUGR babies based on ultrasound growth percentile, Doppler fetal and maternal flow and fetal heart rate status in order to identify some alarm sign that determines the pregnancy conclusion. OP23.11 Perinatal outcome of idiopathic small for gestational age (SGA) babies ≤ 3rd centile amongst women of Bangladesh origin S. Sivarajan , P. Somaiya, R. Hamoudi, M. Keenan, J. Aquilina, L. Wee Obstetrics and Gynaecology, Royal London Hospital, London, United Kingdom Objective: To evaluate perinatal outcome in SGA babies with birth weight ≤ 3rd centile. Design: Case control analysis of term pregnancies in Bangladeshi women delivering babies with birth weight ≤ 3rd centile over one year period at The Royal London Hospital. Control group were Bangladeshi women with birth weight > 10th centile Methodology: The patient’s maternal characteristics and birth details were obtained from Electronic patient record and compared with 138 Ultrasound in Obstetrics & Gynecology 2009; 34 (Suppl. 1): 62–176