DMD #21055 1 The Functional Consequences of Active Hepatic Uptake on CYP Inhibition in Rat and Human Hepatocytes KEN GRIME, PETER JH WEBBORN AND ROBERT J RILEY Department of Discovery DMPK, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough, LE11 5RH, UK (KG, PJW, RJR) DMD Fast Forward. Published on May 12, 2008 as doi:10.1124/dmd.108.021055 Copyright 2008 by the American Society for Pharmacology and Experimental Therapeutics. This article has not been copyedited and formatted. The final version may differ from this version. DMD Fast Forward. Published on May 12, 2008 as DOI: 10.1124/dmd.108.021055 at ASPET Journals on May 1, 2016 dmd.aspetjournals.org Downloaded from