Hindawi Publishing Corporation
Case Reports in Oncological Medicine
Volume 2013, Article ID 695450, 4 pages
http://dx.doi.org/10.1155/2013/695450
Case Report
Signet Cell Carcinoma of Colon in a Nineteen-Year-Old Patient:
A Case Report
Özgül Pamukçu,
1
Fatih Selcukbiricik,
2
Ahmet Bilici,
2
Damlanur SakJz,
3
Osman ÖzdoLan,
4
and Fatih Borlu
1
1
Department of Internal Medicine, S ¸is ¸li Etfal Training Hospital, 34360 Istanbul, Turkey
2
Department of Medical Oncology, S ¸is ¸li Etfal Training Hospital, 34360 Istanbul, Turkey
3
Department of Pathology, S ¸is ¸li Etfal Training Hospital, 34360 Istanbul, Turkey
4
Department of Gastroenterohepatology, S ¸is ¸li Etfal Training Hospital, 34360 Istanbul, Turkey
Correspondence should be addressed to
¨
Ozg¨ ul Pamukc ¸u; pamgul@hotmail.com
Received 11 December 2012; Accepted 4 January 2013
Academic Editors: S. B. Chichareon and K. Tanaka
Copyright © 2013
¨
Ozg¨ ul Pamukc ¸u et al. his is an open access article distributed under the Creative Commons Attribution License,
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Signet cell carcinoma, which is a subtype of adenocarcinoma, usually originates from the stomach. However, it can also originate
from the colon, rectum, gallbladder, pancreas, urinary bladder, and breast. We represent a 19-year-old boy diagnosed with signet
cell tumour while he was being evaluated for an initial diagnosis of inlammatory bowel disease.
1. Introduction
Globally, CRC is the third most commonly diagnosed cancer
in males and the second in females, with over 1.2 million
new cases and 608,700 deaths estimated to have occurred in
2008 [1]. According to the World Health Organization data,
about 608.000 deaths from colorectal cancer are estimated
worldwide, accounting for 8% of all cancer deaths, making
it the fourth most common cause of death from cancer [2].
Colorectal cancer is a common malignancy in adults
which peaks around 6th or 7th decades of life. However, less
than 20% of the colorectal cancer cases can be seen before the
age of 50 [3]. And in USA it was reported that less than 1% of
all cancers are colorectal cancers in the irst two decades of
life [4, 5]. While signet cell carcinoma is a poor diferentiated
type of adenocarcinoma and behaves more aggresively than
ordinary adenocarcinoma of colon, it is more common in
younger patients (especially under 40) compared to other
types [6].
Because of the lack of awareness at early age and the
aggressive characteristic of the tumour, signet ring cell car-
cinomas of the colon mostly present as advanced stage. In
this case report, we report a 19-year-old boy who we were
evaluating for an initial diagnosis of inlammatory bowel
disease was our irst diagnosis. We have interned patient with
that initial diagnosis.
2. Case
A 21-year-old boy who has been evaluated in emergency
service with abdominal pain was referred to our outpatient
clinic because of the reason that there was seen edema
and inlammation around the ileal wall and some collection
regarding the initial diagnosis of inlammatory bowel disease
in the CT scan performed to exclude acute abdomen. he
patient has no family history of any cancer. In his physical
examination, mildtenderness has been detected in the right
lower quadrant and periumblical site of the abdomen. His
bowel sounds were normal and in his rectal examination,
there was a formed stool without blood. In his laboratory
results, pathological results were as follows: CRP: 25; ESR:
22 and fecal occult blood test was positive. In his CT/CT
enterography there was seen free subhepatic and pelvic
abdominal luid; asimetric thickening in the sigmoid colon
walls; derangement of bowels and peritoneum. According
to these indings the radiologists pointed that it must be
evaluated not only for inlammatory bowel disease but also