Incidental 11 C-Choline PET/CT Brain Uptake due to Meningioma in a Patient Studied for Prostate Cancer Correlation With MRI and Imaging Fusion Francesco Bertagna, MD,* Giovanni Bosio, MD,* Lorenzo Pinelli, MD,Þ Giorgio Treglia, MD,þ and Raffaele Giubbini, MD, Prof * Abstract: We report a case of a 75-year-old male patient treated with radio- therapy in 1999 for prostate cancer. Due to a rise in prostate-specific antigen, he underwent 11 C-choline PET/CT. The study was negative for secondary lesions but revealed an incidental pathologic focal brain uptake. A subsequent magnetic resonance examination confirmed the presence of a brain lesion typical for meningioma. Key Words: 11 C-choline, PET/CT, MRI, meningioma (Clin Nucl Med 2013;38: e435Ye437) REFERENCES 1. Treglia G, Giovannini E, Di Franco D, et al. The role of positron emission to- mography using carbon-11 and fluorine-18 choline in tumors other than pros- tate cancer: a systematic review. Ann Nucl Med. 2012;26:451Y461. 2. Milker-Zabel S, Zabel A, Schulz-Ertner D, et al. Fractionated stereotactic radiotherapy in patients with benign or atypical intracranial meningioma: long-term experience and prognostic factors. Int J Radiat Oncol Biol Phys. 2005;61:809Y816. 3. Marta GN, Correa SF, Teixeira MJ. Meningioma: review of the literature with emphasis on the approach to radiotherapy. Expert Rev Anticancer Ther. 2011;11:1749Y1758. 4. Cornelius JF, Langen KJ, Stoffels G, et al. PET imaging of meningioma in clinical practice: review of literature and future directions. Neurosurgery . 2012; 70:1033Y1042. 5. Tan H, Chen L, Guan Y, et al. Comparison of MRI, F-18 FDG, and 11 C-choline PET/CT for their potentials in differentiating brain tumor recurrence from brain tumor necrosis following radiotherapy. Clin Nucl Med. 2011;36:978Y981. 6. Giovacchini G, Fallanca F, Landoni C, et al. C-11 choline versus F-18 fluor- odeoxyglucose for imaging meningiomas: an initial experience. Clin Nucl Med. 2009;34:7Y10. 7. Fallanca F, Giovacchini G, Picchio M, et al. Incidental detection by [ 11 C]choline PET/CT of meningiomas in prostate cancer patients. Q J Nucl Med Mol Imaging. 2009;53:417Y421. 8. Schillaci O, Calabria F, Tavolozza M, et al. 18 F-Choline PET/CT physiological distribution and pitfalls in image interpretation: experience in 80 patients with prostate cancer. Nucl Med Commun. 2010;31:39Y45. INTERESTING IMAGE Clinical Nuclear Medicine & Volume 38, Number 11, November 2013 www.nuclearmed.com e435 Received for publication May 24, 2012; revision accepted October 15, 2012. From the *Department of Nuclear Medicine and †Neuroradiology, University of Brescia and Spedali Civili Brescia, Brescia; and ‡Department of Nuclear Medicine, Catholic University of Sacred Heart, Rome, Italy. Conflicts of interest and sources of funding: none declared. Reprints: Francesco Bertagna, MD, Department of Nuclear Medicine, University of Brescia and Spedali Civili di Brescia, P.le Spedali Civili, 1 25123 Brescia, Italy. E-mail: francesco.bertagna@spedalicivili.brescia.it. Copyright * 2013 by Lippincott Williams & Wilkins ISSN: 0363-9762/13/3811Ye435 Copyright © 2013 Lippincott Williams & Wilkins. Unauthorized reproduction of this article is prohibited.