YIJOM-2369; No of Pages 6 Please cite this article in press as: Clementini M, et al. Success rate of dental implants inserted in horizontal and vertical guided bone regenerated areas: a systematic review, Int J Oral Maxillofac Surg (2012), doi:10.1016/j.ijom.2012.03.016 Review Paper Dental Implants Success rate of dental implants inserted in horizontal and vertical guided bone regenerated areas: a systematic review M. Clementini, A. Morlupi, L. Canullo, C. Agrestini, A. Barlattani: Success rate of dental implants inserted in horizontal and vertical guided bone regenerated areas: a systematic review. Int. J. Oral Maxillofac. Surg. 2012; xxx: xxx–xxx. # 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved. M. Clementini 1 , A. Morlupi 1 , L. Canullo 2 , C. Agrestini 2 , A. Barlattani 1 1 Department of Dentistry, University ‘‘Tor Vergata’’, Rome, Italy; 2 Private Practice, Rome, Italy Abstract. This study assessed the success rate of implants placed in horizontal and vertical guided bone regenerated areas. A systematic review was carried out of all prospective and retrospective studies, involving at least five consecutively treated patients, that analysed the success rate of implants placed simultaneously or as second surgery following ridge augmentation by means of a guided bone regeneration (GBR) technique. Studies reporting only the survival rate of implants and studies with a post-loading follow up less than 6 months were excluded. From 323 potentially relevant studies, 32 full text publications were screened and 8 were identified as fulfilling the inclusion criteria. The success rate of implants placed in GBR augmented ridges ranged from 61.5% to 100%; all studies, apart from three, reported a success rate higher than 90% (range 90–100%). The data obtained demonstrated that GBR is a predictable technique that allows the placement of implants in atrophic areas. Despite that, studies with well-defined implant success criteria after a longer follow-up are required. Accepted for publication 16 March 2012 Dental rehabilitation of partially or totally edentulous patients with oral implants is a valid method for restoring oral aesthetics and function with predictable results. 1–9 A minimum amount of bone width and height is essential for the successful pla- cement of implants. 5,10 Unfavourable local conditions, due to atrophy, trauma and periodontal disease, may provide insufficient bone volume or an unfavour- able interarch relationship, which does not allow correct and a prosthodontically guided positioning of dental implants. 10 Many techniques have been developed to reconstruct deficient alveolar jaws for the placement of dental implants performed either in combination or in second stage surgery after a period of healing. 11 The development of the guided bone regenera- tion (GBR) technique started in the late 1980s with a series of experimental studies. Then clinicians started to use barrier mem- branes in implant patients for various clin- ical indications. 12,13 Int. J. Oral Maxillofac. Surg. 2012; xxx: xxx–xxx doi:10.1016/j.ijom.2012.03.016, available online at http://www.sciencedirect.com 0901-5027/000001+06 $36.00/0 # 2012 International Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.