Pandey Punam et al JMSCR Volume 3 Issue 1 January 2015 Page 3956 JMSCR Volume||03||Issue||01||Page 3956-3965||January 2015 Survival Analysis of 250 Gallbladder Cancer Patients: A Prospective Study over a period of 2 Year Authors Pandey Punam 1 , Singh K.K. 2 , Pandey M. 3 Shukla V.K. 1 1 Department of General Surgery, 2 Departments of Statistics 3 Department of Surgical Oncology IMS, BHU, Varanasi, UP, India Corresponding Author Pandey Punam Department of General Surgery, IMS, BHU, Varanasi, UP, India Email: punampandey38@gmail.com Abstract Background and Aims: The cancer of the Gallbladder are the tumors with a poor prognosis and a lower quality of life (QoL). The aim of this study was to evaluate the survival rate in Cancer of the gallbladder patients. Method: We prospectively enrolled 250 patients diagnosed with the cancer of the gallbladder in the cancer units of university hospital Varanasi, UP, each patient was reviewed, over a 9-month or till death within the period of (2011-2013). Results: The mean age of the patients was 53 ± 10 years: 22.4% were male and 77.6% of the patients were female. Total number of patients in study were 250 at nine month only 23 patient was alive. The univariate analysis showed Age of the patients, tumor cell differentiation, Grade, preoperative lymph node metastasis, response of the patients and the surgical approach significantly correlated with median survival time, the prognosis of the patients was found to be negatively significant (p <0.05). The results of the multivariate analysis (Cox regression) showed age, grade and the surgical approach, lymph node involvement, patients response were independent predicators with relative risks of .74, .52, .47, and .66, respectively found to be significant (p=0.00, 0.01, 0.02, 0.00). Conclusion: The highest 9 month survival rate was 9.2%. Slightly longer survival was recorded when surgery and chemotherapy was added as treatment surgery improved the QOL faster than other treatment. Age, grade and the surgical approach, lymph node involvement, patients response were independent predicators of patient’s survival respectively found to be significant. Key words: – survival – quality of life- adjuvant chemotherapy – curative surgery –prognosis- resectable www.jmscr.igmpublication.org Impact Factor 3.79 ISSN (e)-2347-176x