1 Author’s PRE-PRINT version Publisher version: Radiother Oncol (2015), http://dx.doi.org/10.1016/j.radonc.2015.07.051 Modeling the risk of radiation-induced lung fibrosis: irradiated heart tissue is as important as irradiated lung Laura Cella a* , Vittoria D’AǀiŶo a , Giuseppe Palma a , Manuel Conson a,b , Raffaele Liuzzi a , Marco Picardi c , Maria Cristina Pressello d , Genoveva Ionela Boboc e , Roberta Battistini f , Vittorio Donato e , Roberto Pacelli a,b a Institute of Biostructure and Bioimaging, National Research Council (CNR), Naples, Italy b Department of Advanced Biomedical Sciences, Federico II University School of Medicine, Naples, Italy c Department of Clinical Medicine and Surgery, Federico II University School of Medicine, Naples, Italy d Department of Health Physics, S. Camillo-Forlanini Hospital, Roma, Italy e Department of Radiation Oncology, S Camillo-Forlanini Hospital, Rome, Italy f Department of Hematology, S Camillo-Forlanini Hospital, Rome, Italy Corresponding author: *Laura Cella, Institute of Biostructures and Bioimaging, National Research Council (CNR), 80131 Naples, Italy. Tel: +39-081-2203427; E-mail: laura.cella@cnr.it Running title: NTCP model of radiation-induced lung fibrosis Keywords: NTCP; bootstrap resampling; dose-mass histogram; radiation-induced lung fibrosis; Hodgkin lymphoma; heart