1 A large-scale association analysis of 68 thyroid hormone pathway genes with serum TSH and FT4 levels Marco Medici 1 , Wendy M van der Deure 1 , Michael Verbiest 1 , Sita H Vermeulen 3,4 , Pia S Hansen 6,8 , Lambertus A Kiemeney 3 , Ad R M M Hermus 5 , Monique M Breteler 2 , Albert Hofman 2 , Laszlo Hegedüs 6 , Kirsten Ohm Kyvik 7,8,9 , Martin den Heijer 3,5 , André G Uitterlinden 1,2 , Theo J Visser 1 , Robin P Peeters 1 1 Department of Internal Medicine, 2 Department of Epidemiology; Erasmus University Medical Center, Rotterdam, The Netherlands; 3 Department of Epidemiology, Biostatistics and HTA, 4 Department of Human Genetics, 5 Department of Endocrinology; Radboud University Nijmegen Medical Center, The Netherlands; 6 Department of Endocrinology and Metabolism, 7 Odense Patient data Exploratory Network (OPEN); Odense University Hospital, Odense, Denmark; 8 The Danish Twin Registry, Epidemiology, Institute of Public Health, 9 Institute of Regional Health Services Research; University of Southern Denmark, Odense, Denmark. Running title: Thyroid hormone pathway genes and TSH/FT4 Words: 3670 Figures: 1 Tables: 3 Corresponding author / to whom reprint requests should be addressed: Robin P Peeters, MD, PhD Room Ee 502a, Department of Internal Medicine Erasmus University Medical Center Dr Molewaterplein 50 Page 1 of 23 Accepted Preprint first posted on 2 March 2011 as Manuscript EJE-10-1130 Copyright © 2011 European Society of Endocrinology.