Genetic Pathways in Colorectal and other Cancers* M. Ilyas, 1 J. Straub, 1 I.P.M. Tomlinson 2 and W.F. Bodmer 1 1 Cancer and Immunogenetics Laboratory, Imperial Cancer Research Fund, Institute of Molecular Medicine, John RadcliVe Hospital, Headington, Oxford OX3 9DU; and 2 Molecular and Population Genetics Laboratory, Imperial Cancer Research Fund, London, U.K. Mohammad Ilyas is an MRC funded Clinician Scientist based in Oxford, U.K. He is fully trained as a diagnostic Histo- pathologist and spent 4 years at the Imperial Cancer Research Fund where he completed his Ph.D. with Sir Walter Bodmer. His current work is a continuation of the work from his Ph.D. into the genetic pathways of colorectal cancer. Josef Straub is post-doctoral fellow in Walter Bodmer's Can- cer & Immunogenetics Laboratory at the Institute of Mole- cular Medicine in Oxford. After his training in Cell Biology at the University of Kaiserslautern/Germany he did his Ph.D. in Molecular Toxicology at the German Cancer Research Centre in Heidelberg/Germany before becoming SKB Junior Research Fellow (Genomics) of Hertford College, Oxford. Ian Tomlinson is Head of the Molecular and Population Genetics Laboratory at the Imperial Cancer Research Fund Laboratories, London, and Honorary Consultant in Cancer Genetics. He gained his Ph.D. in population genetics from Cambridge and then did clinical medicine. He worked with Sir Walter Bodmer as a postdoctoral fellow and has held positions as Senior Clinical Research Fellow at the Institute of Cancer Research and the NuYeld Department of Medicine, John RadcliVe Hospital, Oxford. Walter Bodmer is Principal of Hertford College, Oxford, for- merly Director General of the Imperial Cancer Research Fund, having been Director of Research at the Fund from 1979±1991. He was made a Fellow of the Royal Society in 1974, and received a knighthood in 1986. He continues his scienti®c work, together with his wife, Julia, at their laboratory at the Institute of Molecular Medicine, John RadcliVe Hospi- tal, Oxford. European Journal of Cancer, Vol. 35, No. 14, pp. 1986±2002, 1999 # 1999 Elsevier Science Ltd. All rights reserved Pergamon Printed in Great Britain PII: S0959-8049(99)00298-1 0959-8049/99/$ - see front matter 1986 *Reprinted from Eur J Cancer 1999, 35(3), 335±351. Please use this reference when citing this article. Correspondence to M. Ilyas, e-mail: ilyas@uropa.lif.icnet.uk Received 8 Dec. 1998; accepted 9 Dec. 1998.