PERSONAL USE ONLY Osteosclerotic myeloma associated with spinal tuberculosis with neurological manifestation: A case report Caroline Edijana Omoti 1 , Ogbeide Ehimwenma 2 , Osesogie Usualele Ogbeide 2 1 Department of Haematology, University of Benin Teaching Hospital, Benin City, Nigeria 2 Department of Radiology, University of Benin Teaching Hospital, Benin City, Nigeria Summary Background: Coincidental presentation of osteosclerotic myeloma and spinal tuberculosis is an unusual and rare disease condition. Dissimilar data about diagnosis and treatment from various hospitals and different countries are reported. Spinal tuberculosis is the most dangerous form of tuberculous infection which commonly leads to a gradual onset of neurological deficit that are difficult to di- agnose at the early stage; and its association with osteosclerotic myeloma with multiorgan in- volvement including polyneuropathy, organomegaly, endocrinopathy, monoclonal gammop- athy and skin changes, the so-called “POEMS” syndrome are rare. Case Report: A 57 year old male civil servant was admitted into the medical ward of the University of Benin Teaching Hospital (UBTH) Benin City, Nigeria on July 10 th 2007 on account of one year his- tory of cough, low backache and progressive weight loss. Examination showed grade 2 fin- ger clubbing with leuconychia, sensory loss at T12, L1, and L4 with gibbus formation at T12 L1 which was nontender, bone marrow plasmacytosis (10%), serum protein electrophoresis showed a reduction of circulating IgG monoclonal protein; radiographs of the thoraco-lum- bar spine revealed generalized osteosclerosis of the vertebrae and an anterior wedge fracture of T12, L1 and L4 Conclusions: Coincidental presentation of osteosclerotic myeloma and spinal tuberculosis with neurologi- cal involvement is rare, but has been reported in this case occurring in an African. Effective management of these patients is multidisciplinary. key words: osteosclerotic myeloma • spinal tuberculosis • neurological • peripheral neuropathy Full-text PDF: http://www.amjcaserep.com/fulltxt.php?ICID=864478 Word count: 2009 Tables: — Figures: — References: 34 Author’s address: Caroline Edijana Omoti, Department of Haematology, University of Benin Teaching Hospital, P.M.B. 1111, Benin City, Nigeria, e-mail: ediomoti@yahoo.com Received: 2008.05.07 Accepted: 2008.06.19 Published: 2008.07.18 321 © The AmericanJournal of Case Report, 2008; 9: 321-324 Case Report WWW. AMJCASEREP .COM Electronic PDF security powered by ISL-science.com opy is for personal use only - distribution prohibited. This copy is for personal use only - distribution prohibited. This copy is for personal use only - distribution prohibited. This copy is for personal use only - distribution prohibited. This copy is for personal use only - distribu