This article is protected by copyright. All rights reserved Original Research Article Mitochondrial Dysfunction and Ca 2+ Overload Contributes to Hesperidin Induced Paraptosis in Hepatoblastoma Cells, HepG2 † Silvia Yumnam 1 , Gyeong Eun Hong 1 , Suchismita Raha 1 , Venu Venkatarame Gowda Saralamma 1 , Ho Jeong Lee 1 , Won-Sup Lee 2 , Eun-Hee Kim 3 and Gon Sup Kim 1* 1 Research Institute of Life Science, College of Veterinary Medicine (BK21 plus project), Gyeongsang National University, Gazwa, Jinju 660-701, Republic of Korea. 2 Department of Internal Medicine, Institute of Health Sciences, Gyeongsang National University School of Medicine, Gyeongnam Regional Cancer Center, Gyeongsang National University Hospital, Jinju 660-702, Republic of Korea, 3 Department of Nursing Science, International University of Korea, Jinju 660-759, Republic of Korea. *Corresponding author: Prof. Gon-Sup Kim, Institute of Life science and College of Veterinary Medicine, Gyeongsang National University, Gazwa, Jinju, 660-701, Republic of Korea, Tel.: +82 55 772 2346; Fax: +82 55 772 2349. E-mail address: gonskim@gnu.ac.kr Running Head: Hesperidin induces paraptosis in HepG2 cells. Keywords:  Paraptosis  Hesperidin  HepG2  Mitochondrial Ca 2+  ROS Contract grant sponsor: National Research Foundation (NRF) of Korea funded by the Ministry of Science, ICT & Future Planning and National R&D Program for Cancer Control, Ministry for Health, Welfare and Family Affairs, Republic of Korea. Contract grant numbers: No.2012M3A9B8019303, No. 2012R1A2A2A06045015 and No. 0820050. † This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: [10.1002/jcp.25222] Received 4 June 2015; Revised 19 October 2015; Accepted 20 October 2015 Journal of Cellular Physiology This article is protected by copyright. All rights reserved DOI 10.1002/jcp.25222