784 Examination of the FPG change trajectories showed that the relation between CRF and FPG was negative and that the CRF effect increased with aging after age 40 y. CONCLUSIONS: Aging, BC and CRF are independent determinants of longitudinal changes in FPG. The statistical models showed that FPG increases with aging and adiposity. The inverse effect of CRF on longitudinal changes in FPG is age-related, after age 40 y the CRF effect increases with aging. Supported by NIH Grants AG06945, HL62508, and R21DK088195, and an unrestricted research grant from the Coca-Cola Company. 2787 Board #86 June 3 3:30 PM - 5:00 PM Determinants of Physical Activity in Chronic Heart Failure Paula A. Ribeiro, Marta S. Brod, Jorge P. Ribeiro. Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Email: paulaabribeiro@gmail.com (No relationships reported) BACKGROUND: Patients with chronic heart failure (CHF) have reduced exercise capacity but little is known on the pattern and determinants of their physical activity (PA). PURPOSE: In ambulatory patients with CHF, we evaluated: 1) the prevalence of PA; 2) self-reported and accelerometer measured PA; and 3) the determinants and correlates of PA. METHODS: 52 patients with stable CHF had medical history, maximal cardiopulmonary exercise test, echocardiogram, as well as measurement of inspiratory muscle strength, hand grip strength, and flexibility (Flexitest). Self-reported PA was estimated by the International Physical Activity Questionnaire (IPAQ) and PA was measured by accelerometer monitoring, during 4 days. PA was expressed as the proportion of the international recommendation of 150 min per week in moderate and vigorous activities. Determinants of PA were evaluated by multiple linear regression analysis. RESULTS: The prevalence of active patients was 10% according to accelerometer measurements, and 77% according to IPAQ. Self-reported of PA was not associated with accelerometer-measured moderate and vigorous PA (r = 0.15; p = 0.32). There was a week association with borderline significance between self-reported PA and light accelerometer-measured PA (r = 0.28; p= 0.056). Significant determinants of self-reported PA were age and flexibility (r 2 = 0.325 P=0.001). Only number of drugs was inversely associated with time spent in light PA (r 2 = 0.295; P=0.003). Only level of education was a significant determinant of time spent in moderate plus vigorous accelerator-measured PA (r 2 = 0.211; P=0.05). CONCLUSION: In ambulatory patients with CHF: 1) prevalence of moderate to vigorous accelerometer-measured PA is low; 2) there is poor association between self-reported and accelerometer-measured PA; 3) the determinants of self-reported PA are different from those of accelerometer-measured PA. Since only about 30% of the variance in PA can be accounted by the variables here evaluated, further studies should be conducted to identify other determinants of PA in this patient population. This study received financial support from Hospital de Clínicas de Porto Alegre. 2788 Board #87 June 3 3:30 PM - 5:00 PM Regular Physical Activity Prevents Atherosclerosis In High-risk Patients With Cardiovascular Disease Shinji Nemoto 1 , Minako Yamaoka-Tojo 2 , Kazuki Wakaume 1 , Shuhei Yamamoto 1 , Masahiko Kimura 2 , Misao Ogura 2 , Michitaka Kato 1 , Naoko Aiba 1 , Ryo Kameda 1 , Yoji Machida 3 , Yuki Yoshida 3 , Atsuhiko Matsunaga 2 , Takashi Masuda 2 , Tohru Izumi 3 . 1 Kitasato University Graduate school of Medical Science, Sagamihara, Japan. 2 Kitasato University School of Allied Health Sciences, Sagamihara, Japan. 3 Department of Cardioangiology, Kitasato University School of Medicine, Sagamihara, Japan. (No relationships reported) PURPOSE:Atherosclerosis is the major cause of incidence of cardiovascular mortality. Diet and physical therapy contribute to improve atherogenic condition even in stable ischemic heart disease (IHD) patients given intensive drug therapy. However, the relationship regular physical activity and the progression of atherosclerosis in IHD patients receiving total risk management for heart disease remain unclear. The aim of this study was to clarify the effect of regular physical activity on atherosclerosis in IHD patients with aggressive lipid and glucose lowering therapy (low-density lipoprotein cholesterol [LDL-C] < 120 mg/dL and hemoglobin A1c [HbA1c] < 6.5 %). METHODS: We selected 50 high-risk patients (average age 73.3 years old; 45 males) with stable IHD undergoing total risk management in the Kitasato Registry for Cardiovascular Disease Prevention. Clinical characteristics (sex, age, body mass index, blood pressure, and heart rate), physical activity level, LDL-C, HbA1c, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), brain natriuretic peptide (BNP), and pulse wave velocity (PWV) were measured at baseline, 2 or 3 years later, and 5 years later. The patients were divided into 2 groups based on regular physical activity level with or without accumulate 30 minutes or more of physical activity at least 3 days per week during 5 years. RESULTS: There were no significant differences in clinical characteristics between 2 groups at baseline. The levels of LDL-C, HbA1c, HDL-C, TG and BNP showed no significant changes during 5 years in both groups. In the less regular physical activity group, PWV was significantly increased (14% increase) during 5 years compared with the more regular physical activity group (P=0.002). CONCLUSIONS: Regular physical activity affected on PWV in IHD patients with aggressive lipid and glucose management. These data suggest that even in the setting of intensive drug and diet therapy, regular physical activity is one of the important determinants to inhibit atherosclerosis progression. 2789 Board #88 June 3 3:30 PM - 5:00 PM Age-related Longitudinal Changes in Cardiorespiratory Fitness, Physical activity, and Body Mass Index In Women: Findings From the Aerobics Center Longitudinal Study Xuemei Sui 1 , Jiajia Zhang 1 , Duck-chul Lee 1 , Andrew S. Jackson, FACSM 2 , Steven N. Blair, FACSM 1 . 1 University of South Carolina, Columbia, SC. 2 University of Houston, Houston, TX. Email: msui@gwm.sc.edu (No relationships reported) The patterns of weight change over time, and the role of changing patterns of physical activity, especially in relation to weight, have not been studied extensively. Most studies tracking physical activity or body mass patterns used conventional growth modeling methods. These methods assume the presence of an average trajectory in the underlying population. However, considering population heterogeneity, such assumptions may be too simplistic. PURPOSE: The purpose of this study is to access the longitudinal change of cardiorespiratory fitness (CRF), physical activity (PA), and body mass index (BMI) with aging using the generalized additive model (GAM), which can account any age pattern by the non parametric structure of age function. METHODS: We studied a cohort of 1,798 women, aged 30 to 80 years, from the Aerobics Center Longitudinal Study who completed 3 to 29 health examinations from 1970 to 2006. CRF was measured by a maximal Balke treadmill exercise test. PA was self- reported and the total MET-minutes/week of PA was estimated. BMI was calculated from measured height and weight. Copyright © 2011 by the American College of Sports Medicine. 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