Abstracts of the 4th Biennial Schizophrenia International Research Conference / Schizophrenia Research 153, Supplement 1 (2014) S1–S384 S247 Poster #M156 UNDERSTANDING SOCIAL FUNCTIONINGIN “AT RISKMENTAL STATE” FINDINGS FROM THE ZURICH EARLY RECOGNITION PROGRAM Anastasia Theodoridou 1,2 , Karsten Heekeren 3 , Nicolas Rüsch 4 , Diane N. Dvorsky 2 , Mario Müller 2 , Sibylle Metzler 2 , Susanne Walitza 5 , Wulf Rössler 2 1 University Hospital of Psychiatry Zurich, Switzerland; 2 University Hospital of Psychiatry Zurich, The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Switzerland; 3 The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric Hospital, University of Zurich, Switzerland; 4 Dept. of Psychiatry II, University of Ulm, Germany; 5 Dept. of Child and Adolescent Psychiatry Background: Poor social functioning is one of the diagnostic criteria of schizophrenia in DSM-5. Part of the disability produced by psychotic illnesses especially schizophrenia and bipolar disorder develops already during the prepsychotic period. Internationally employed definitions of the “at risk mental state” are existing. Previous studies found that low func- tioning in an “at-risk mental state” is associated with higher conversion rates. Disability plays also a role in a putative “attenuated psychosis risk syndrome”. This study aims to explore possible predictors and mediators of functioning. Methods: In this prospective longitudinal multi-level-approach (psy- chopathology, neuropsychology, genetic, electrophysiology, sociophysiol- ogy/social cognition, MRI and NIRS) subjects, at risk for schizophrenia or bipolar disorder, from the Canton Zurich were recruited. In our symptomatic high-risk group we target these individuals for intensive monitoring. Data about the socio-demographic background, physical health, obstetric and family history, premorbid adjustment, functioning and disability by psychi- atric symptoms, daily hassles stress and quality of life, perceived stigma, general self-esteem, social distance were collected. To model simultane- ously the relations of clinical and socio-demographic variables with the dependent variables, path analysis models will be used. Results: Participant baseline characteristics and descriptive data: 221 per- sons entered the study group. 133 (60.2%) subjects were male. The mean age of the sample was 20.99 (±6.0) years (range 13-35 years, median 20 years) with no significant difference between males (21.25±6.1 years) and females (20.60±5.7 years). Among the 221 participants, 81 (36.7%) fulfilled high risk and 107 (48.4%) ultra-high risk criteria for psychosis, 155 (70%) fulfilled risk criteria for bipolar disorder. Discussion: We found a huge overlap between the different at-risk groups. In this study we examined the underlying processes of social functioning deficits and their associations in a population of individuals with a high risk for psychosis. Understanding etiologically factors, underlying psychosocial functioning, could have an impact on refined intervention strategies. Poster #M157 THE DANISH HIGH RISK AND RESILIENCE STUDY- VIA 7-ATTACHMENT STYLE, HOME ENVIRONMENT AND EMOTIONAL CLIMATE AMONG 7-YEAR- OLD CHILDREN WITH FAMILIAR HIGH RISK OF DEVELOPING SCHIZOPHRENIA SPECTRUM DISORDER OR BIPOLAR DISORDER Anne A.E. Thorup 1,2 , Nicoline Hemager 3,4 , Jens Richardt Jepsen 5 , Camilla Jerlang Christiani 5 , Anne Ranning 5 , Ditte Lou Gantriis 6 , Aja Greve 7 , Mette Skærbæk 5 , Niels Ole Mors 6 , Merete Nordentoft 8 , Kerstin Jessica Plessen 9 1 Mental Health Services, Capital Region of Denmark, University of Copenhagen, Faculty of Health and Medical Sciences; 2 Mental Health Services, Capital Region of Denmark, Mental Health Centre for Child and Adolescent Psychiatry, University of Copenhagen, Faculty of Health and Medical Sciences; 3 Mental Health Services, Capital Region of Denmark, Mental Health Centre; 4 University of Copenhagen, Faculty of Health and Medical Sciences; 5 Mental Health Services, Capital Region of Denmark, Mental Health Centre; 6 Risskov, University of Aarhus, Faculty of Health Sciences; 7 University of Aarhus, Faculty of Health Sciences; 8 Mental Health Services, Capital Region of Denmark, Mental Health Centre; University of Copenhagen, Faculty of Health and Medical Sciences; 9 Mental Health Services, Capital Region of Denmark, Mental Health Centre for Child and Adolescent Psychiatry Background: Background The dominating hypothesis is that schizophrenia is a neurodevelopmental disorder, and that both genes, environment and gene-environment-interactions contribute to the risk of developing the disease. Children of parents with schizophrenia have a higher risk of devel- oping a serious mental illness during life and, as a group, they have a higher rate of developmental abnormalities, emotional and social difficulties, and cognitive problems compared to children without genetic disposition. Focus on the child’s attachment style and upbringing conditions Recent evidence has highlighted the importance of attachment style and the child’s sub- jective experiences of the quality of care and support from the parents for the development of future mental health. Insecure and disorganized attachment styles are viewed as risk factors for being more vulnerable to developing emotional difficulties, poorer emotional control, lower self- esteem, and poorer mentalization etc. which may lead to a higher risk of developing mental disorders. In this context, the home environment and the circumstances under which the child is raised with varying degrees of stimulation and support, represents an important prognostic factor. Aim We aim to analyse the influences of genetic risk and environmental factors, including childhood rearing conditions, in a population of 7-year-old chil- dren with either 0, 1 or 2 parents diagnosed with schizophrenia spectrum psychosis or bipolar disorder on their cognitive, neuromotor, and psychoso- cial development and on the presence of psychopathology. We hypothesize that a larger percentage of the children growing up with a parent suffering from a severe mental disorder like schizophrenia or bipolar disorder, will display insecure or disorganized attachment patterns, compared with the children of parents without these disorders. Methods: Design and method We are establishing a cohort of 500 children and their parents, who will be assessed with a comprehensive test battery, where cognition, behaviour, psychopathology and neuromotor develop- ment of the child are the main outcome measures. Both parents and the child will be examined with a wide range of validated instruments, inter- views, tests, observations and questionnaires to map these domains. The participants are recruited via Danish Registers to ensure representativity. Data from registers concerning social status, birth complications, somatic illnesses and hospitalization will be included in the database. In addition, we also map psychological and relational factors, such as the emotional climate around the child, the degree of stimulation and support in the home environment, and the perceived support from the social network of the parents, the parents attachment style and finally the child’s attachment patterns. Results: Status/results Data collection started 15 December 2012 and is very successful in terms of making the families positive for participation. About 80% of the invited families accept to participate, equal for all groups, and drop-out rates are very low. 150 families are included in the study by Dec 3. Results will be available from 2015. Discussion: Method and background will be discussed Poster #M158 NEURAL CORRELATES OF REWARD PROCESSINGIN UNMEDICATED PERSONS AT-RISK FOR PSYCHOSIS Diana Wotruba 1,2 , Karsten Heekeren 1 , Lars Michels 2 , Buechler Roman 1 , Joe J. Simon 3 , Ana Theodoridou 1 , Spyros Kollias 2 , Wulf Roessler 1 , Stefan Kaiser 4 1 The Zurich Program for Sustainable Development of Mental Health Services (ZInEP), Psychiatric Hospital, University of Zurich, Switzerland; 2 Clinic of Neuroradiology, University Hospital of Zurich, Zurich, Switzerland; 3 Department of General Internal Medicine and Psychosomatics, Medical University of Heidelberg, Heidelberg, Germany; 4 Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric Hospital, University of Zurich, Switzerland Background: Alterations of the brain reward system have been related to both positive and negative symptoms in schizophrenia. Only recently, positron emission tomography studies have suggested that dopaminergic dysregulation begins before the first psychotic episode. However, the re- lationship between functional activation in response to rewards has not yet been investigated in an unmedicated at-risk sample. Thus, the aim of this study was to examine the neural response to reward expectation and reward outcomes in unmedicated participants at-risk for psychosis com- pared to healthy adults. We were particularly interested whether neural activity in reward and salience associated areas (i.e. ventral Striatum (VS),