Abstract—The new paradigm of e-Health demands open sensors and middleware components that permit transparent integration and end-to-end interoperability of new personal health devices. The use of standards seems to be the internationally adopted way to solve these problems. This paper presents the implementation of an end-to-end standards- based e-Health solution. This includes ISO/IEEE11073 standard for the interoperability of the medical devices in the patient environment and EN13606 standard for the interoperable exchange of the Electronic Healthcare Record. The design strictly fulfills all the technical features of the most recent versions of both standards. The implemented prototype has been tested in a laboratory environment to demonstrate its feasibility for its further transfer as real solution to the healthcare system. I. INTRODUCTION nteroperable exchange of information can be understood as huge benefits for health systems and telemedicine programs: patients will enhance information about their health and doctors have the ability to easily monitor vital signs. Thus, the interoperability of Medical Devices (MDs) and Personal Health Devices (PHDs) from different vendors and the integrated exchange between heterogeneous Health Care Information Systems (HCIS) through standardization are basic requirements in the design of new personal health solutions. In this context, ISO/IEEE11073 (X73) [1] for interoperability of MDs and PHDs, and EN13606 [2] for Electronic Healthcare Record (EHR) exchange are the two standards called to solve this interoperability leak and support the implementation proposed in this paper. X73 [1] was initially designed in 2004 to address Intensive Care Units scenarios covering MD communication at the Point-of-Care of the patient (X73PoC). With the emergence of new transmission technologies and wearable devices, the standard has evolved to the most recent version Manuscript received April 23, 2010. This research work has been partially supported by projects TIN-2009-08414 and TIN-2008-00933/TSI from Comisión Interministerial de Ciencia y Tecnología (CICYT) and European Regional Development Fund (ERDF), TSI-020302-2009-89 and TSI-020302-2009-7/Plan Avanza I+D from Ministerio de Industria, Turismo y Comercio, and FPI grant to M.Martínez-Espronceda (Res.1342/2006 Public University of Navarre). I. Martínez, P.del Valle, P. Muñoz, J. D. Trigo, J. Escayola, and J. García are with the Communications Technologies Group (GTC), Aragón Institute of Engineering Research (I3A), University of Zaragoza UZ), c/María de Luna, 1 – 50018 Zaragoza, Spain (corresponding e-mail: imr@unizar.es). M. Martínez-Espronceda and L. Serrano are with the Electrical and Electronics Engineering Dept., Public University of Navarre (UPNA), Campus de Arrosadía, s/n – 31006 Pamplona, Spain. A. Muñoz is with Telemedicine and Information Society Dept. Health Institute “Carlos III” (ISCIII), c/Sinesio Delgado, 4 – 28029 Madrid, Spain. for PHDs: X73PHD. EN13606 [2] has strongly evolved from lasts two decades until it has been completed in 2010. It allows representing any information included in the EHR, as well as its communication between EHR systems, managing semantic interoperability of the transmitted data. EN13606 is based on a dual model: Reference Model (that supports information and is defined by kinds of top-down structures: extract, folder, composition, section, entry, cluster, and element) and Archetype Model (that define “knowledge”: an archetype is a pattern that represents the specific characteristic of the clinical data). One of the main challenges in the standard-based design is to overcome the resistance from the manufacturers to adopt the new standards for its further implementation in solutions transferable to the healthcare system [3], [4]. Several previous contributions have been developed in order to implement a standard-based platform for e-Health [5], [6]. Figure 1 shows the evolution in the last year. The first 1.0- αlpha platform [5] was focused on PoC for fixed scenarios by integrating X73PoC and ENV13606. The second 1.5-βeta platform [6], also for fixed scenarios, evolved to PHD with independent transport layer, episodic sending data for Protocol Data Units (PDUs) and a plug-and-play and optimized Finite State Machine (FSM). The last 2.0-BT platform, presented in this paper, evolves for wireless and personal scenarios over Bluetooth technologies. Bluetooth is a specification for Wireless Personal Area Networks (WPANs) that enables communication between devices via secure and free radio link (2.4 GHz). Currently, there are many manufacturers that already incorporate Bluetooth technology into the design of MDs and PHDs, but they are still releasing their own proprietary solutions while X73PHD is leading to a consolidated status. Nevertheless, since USB and Bluetooth have been adopted as a transport layer technologies for the X73PHD communication stack by the Continua Health Alliance, in last months, new MDs and PHDs have been developed fulfilling the Continua Certification [7]. Thus, this paper covers the design and implementation of the 2.0-BT platform for personal healthcare through X73PHD and EN13606 standards over Bluetooth. Section II analyses the standard-based design of the proposed solution, detailing its key aspects and technical characteristics. Section III describes the end-to-end implementation and Section IV presents the results obtained with a blood pressure on Bluetooth technology and a wireless manager on HTC-3G SmartPhone. The conclusions and future lines of work overall are discussed in Section V. Interoperable and Standard e-Health Solution over Bluetooth I. Martínez, P. del Valle, P. Muñoz, J.D. Trigo, J. Escayola, M. Martínez-Espronceda, A. Muñoz, L. Serrano, Senior Member IEEE, J. García, Member IEEE I