Research Article Correlation of Papillomacular Nerve Fiber Bundle Thickness with Central Visual Function in Open-Angle Glaucoma Wataru Kobayashi, 1 Hiroshi Kunikata, 1,2 Kazuko Omodaka, 1 Kyousuke Togashi, 3 Morin Ryu, 1 Masahiro Akiba, 4 Gaku Takeuchi, 4 Tetsuya Yuasa, 3 and Toru Nakazawa 1,2,5 1 Department of Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan 2 Department of Retinal Disease Control, Ophthalmology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan 3 Department of Bio-Systems Engineering, Faculty of Engineering/Graduate School of Science and Engineering, Yamagata University, 4-3-16 Jonan, Yonezawa-shi, Yamagata 992-8510, Japan 4 Topcon Corporation, 75-1 Hasunuma-cho, Itabashi-ku, Tokyo 174-8580, Japan 5 Department of Advanced Ophthalmic Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan Correspondence should be addressed to Toru Nakazawa; ntoru@oph.med.tohoku.ac.jp Received 25 December 2014; Accepted 14 February 2015 Academic Editor: Van C. Lansingh Copyright © 2015 Wataru Kobayashi et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Purpose. To determine the correlation of reduced retinal thickness in the central papillomacular bundle (CPB) to central visual function, including central retinal sensitivity and visual acuity, in glaucoma patients. Methods. his study enrolled 50 eyes of 50 patients with open-angle glaucoma who were carefully screened for comorbid conditions that can cause decreased central visual function, such as cataracts or macular diseases. We used a novel CPB analysis comprising a program for optical coherence tomography that measured RNFL thickness and GCC thickness in the CPB and divided lengthwise into three parts (upper, middle, and lower CPB). he relationship of these parameters, including conventional macular thickness, to visual ield sensitivity in four central standard automated perimetry points (the central four thresholds) and BCVA was analyzed. Results. he two parameters most highly correlated with central four thresholds were macular GCCT and macular RNFLT. he two parameters most highly correlated with BCVA were middle CPB (mid-CPB) GCCT and mid-CPB RNFLT. A multiple regression analysis revealed that mid-CPB GCCT was an independent factor impacting central retinal thresholds and BCVA. Conclusions. Our results suggest that mid-CPB RNFLT and GCCT, parameters of a novel papillomacular bundle analysis, are candidate biomarkers of decreased central visual function in glaucomatous eyes. 1. Introduction Glaucoma afects over 70 million people worldwide and is currently the second most common cause of blindness [1, 2]. It is characterized by reduction of the retinal ganglion cell layer (GCL) and loss of the axons comprising the retinal nerve iber layer (RNFL) [3]. he incidence of glaucoma increases with age [4], and glaucoma-induced visual disorder is becoming an increasingly serious problem in an aging society. A major risk factor for glaucoma is high intraocular pressure (IOP), and treatment to lower IOP is commonly recommended to patients with glaucoma [5, 6]. Macular functions, including visual acuity (VA) and retinal sensitivity, are very important for quality of life even in patients with glaucoma [7]. hough VA is generally preserved until the late stages of glaucoma [8], cases have also been reported of patients whose VA decreased even in the early stages of the disease [9, 10]. Recently, spectral domain opti- cal coherence tomography (SD-OCT) technology has been introduced, which enables us to visualize and quantify each Hindawi Publishing Corporation Journal of Ophthalmology Volume 2015, Article ID 460918, 6 pages http://dx.doi.org/10.1155/2015/460918