Research Article The Influence of BMX Gene Polymorphisms on Clinical Symptoms after Mild Traumatic Brain Injury Yu-Jia Wang, 1,2 Yu-Wen Hsu, 3 Che-Mai Chang, 3 Chung-Che Wu, 4 Ju-Chi Ou, 5 Yan-Rou Tsai, 1 Wen-Ta Chiu, 6 Wei-Chiao Chang, 2,3,7 Yung-Hsiao Chiang, 1,4,8 and Kai-Yun Chen 1,8 1 Graduate Institute of Neural Regenerative Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei 11031, Taiwan 2 Department of Pharmacy, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan 3 Department of Clinical Pharmacy, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan 4 Department of Neurosurgery, Taipei Medical University Hospital, Taipei 11031, Taiwan 5 Department of Emergency Medicine, Shuang-Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan 6 Ministry of Health and Welfare, Taipei 10341, Taiwan 7 Master Program for Clinical Pharmacogenomics and Pharmacoproteomics, School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan 8 Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 11031, Taiwan Correspondence should be addressed to Kai-Yun Chen; chenkathryn@hotmail.com Received 30 December 2013; Accepted 4 March 2014; Published 22 April 2014 Academic Editor: Shuen-Iu Hung Copyright © 2014 Yu-Jia Wang et al. his is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Mild traumatic brain injury (mTBI) is one of the most common neurological disorders. Most patients diagnosed with mTBI could fully recover, but 15% of patients sufer from persistent symptoms. In recent studies, genetic factors were found to be associated with recovery and clinical outcomes ater TBI. In addition, results from our previous research have demonstrated that the bone marrow tyrosine kinase gene in chromosome X (BMX), a member of the Tec family of kinases, is highly expressed in rats with TBI. herefore, our aim in this study was to identify the association between genetic polymorphisms of BMX and clinical symptoms following mTBI. Four tagging single nucleotide polymorphisms (tSNPs) of BMX with minimum allele frequency (MAF) >1% were selected from the HapMap Han Chinese database. Among these polymorphisms, rs16979956 was found to be associated with the Beck anxiety inventory (BAI) and dizziness handicap inventory (DHI) scores within the irst week ater head injury. Additionally, another SNP, rs35697037, showed a signiicant correlation with dizziness symptoms. hese indings suggested that polymorphisms of the BMX gene could be a potential predictor of clinical symptoms following mTBI. 1. Introduction Traumatic brain injury (TBI) is an important cause of mortality and disability worldwide. TBI is usually caused by a blunt or penetrating trauma or an external force to the head, leading to damage of the normal function of the brain [1]. he neurobiological damage following TBI is a complex mechanism, which causes long-term physical, cognitive, and emotional impairment, resulting in enormous medical and social expenses. TBI can be classiied as mild, moderate, and severe according to Glasgow Coma Scale (GCS) categories [2]. Among these three classiications, mild TBI (mTBI) constitutes most instances of TBI each year [3]. Most patients diagnosed with mTBI recover fully within days to months, but up to 15% of patients will continue to experience persistent functional or emotional symptoms [4, 5]. To discover reliable genetic biomarkers for recovery from TBI, recent studies have focused on associations between genetic factors and neuroscience [6–8]. Previous genetic association studies have indicated that genetic susceptibility is related to recovery and clini- cal outcomes following TBI. Genetic variations of the Hindawi Publishing Corporation BioMed Research International Volume 2014, Article ID 293687, 7 pages http://dx.doi.org/10.1155/2014/293687