Assessing cognitive deficits in bipolar disorder: Are self-reports valid? B Katherine E. Burdick a, * ,1 , Carrie J. Endick b,2 , Joseph F. Goldberg a,2 a Department of Psychiatry Research, Zucker Hillside Hospital, North Shore Long Island Jewish Health System, 75–59 263rd Street, Glen Oaks, NY 11004, USA b Department of Psychiatry, Northwestern University School of Medicine, Chicago, IL, USA Received 27 April 2004; received in revised form 11 November 2004; accepted 3 December 2004 Abstract Patients with affective disorders frequently report problems with attention, concentration and memory, although little research has investigated subjective cognitive complaints relative to objective neuropsychological deficits. We compared subjective (self-rated) cognition and objective (clinician-rated) neuropsychological functioning in 37 DSM-IV bipolar out- patients. Subjects completed three standardized self-report inventories: the Cognitive Difficulties Scale (CDS), Cognitive Failures Questionnaire (CFQ), and Patient’s Assessment of Own Functioning (PAOF). These were followed by a systematic neuropsychological test battery. More than 75% of our sample of bipolar patients displayed some cognitive deficits, most notably in the domains of verbal learning and memory. In general, patients’ self-reports of impairment failed to reliably predict objective neuropsychological deficits. Mood ratings for mania and depression were not significantly correlated with any of the self-report inventories or the objective neuropsychological variables. The findings suggest that most bipolar patients demon- strate objective signs of cognitive impairment, but they are unable to report them accurately, at least using available self-report inventories. Such discrepancies could relate to impaired insight, efforts to conceal deficits, or to subthreshold affective symptoms. D 2005 Elsevier Ireland Ltd. All rights reserved. Keywords: Cognition; Memory; Attention; Bipolar disorder; Neuropsychology; Memory; Self-assessment 0165-1781/$ - see front matter D 2005 Elsevier Ireland Ltd. All rights reserved. doi:10.1016/j.psychres.2004.12.009 B Presented, in part, at the 154th Annual Meeting of the American Psychiatric Association, New Orleans, LA, USA, May 10–14, 2001. * Corresponding author. Tel.: +1 718 470 8167; fax: +1 718 343 1659. E-mail address: Kburdick@lij.edu (K.E. Burdick). 1 At the time of writing, affiliation was Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. 2 At the time of writing, affiliation was Department of Psychiatry, Weill Medical College of Cornell University and Bipolar Disorders Research Clinic, New York Presbyterian Hospital, New York, NY, USA. Psychiatry Research 136 (2005) 43 – 50 www.elsevier.com/locate/psychres