264 MED ARH 2010; 64(5) • ORIGINAL PAPER Correlation of Arterial Hypertension and Type 2 Diabetes Mellitus with Type of Polyvascular Atherosclerotic Disease ORIGINAL PAPER Correlation of Arterial Hypertension and Type 2 Diabetes Mellitus with Type of Polyvascular Atherosclerotic Disease Mirza Dilic 1 , Alen Dzubur 2 , Zumreta Kusljugic 3 , Sefkija Balic 4 , Esad Pepic 5 Clinic of Vascular Diseases, Clinical Center University of Sarajevo, Bosnia and Herzegovina 1 Clinic of Heart Diseases and Rheumatism, Clinical Center University Sarajevo, Bosnia and Herzegovina 2 Department of Cardiology, University Clinical Center of Tuzla, Tuzla, Bosnia and Herzegovina 3 Clinic od Endocrinology and Diabetes, Clinical Center University of Sarajevo, Bosnia and Herzegovina 4 Institute of Patophysiology, Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina 5 A therosclerosis is a systemic disease of blood vessels which in most of the cases afects two or three vascular beds. he occurrence and development of atherosclerotic disease is accelerated by multiple risk factors among which the signiicant role has arterial hypertension and diabetes mellitus. Aim of this article is to evaluate presence of hypertension and diabetes mellitus type 2 in patients with polyvascular atherosclerotic disease and compare them to those who have isolated disease of one vascular bed. Material and methods: we enrolled total of 160 consecutive patients. Patients were divided into 4 groups, in relation to the type of their athero- sclerotic disease. COR-group included patients with coronary atherosclerotic disease, CAR-IF group included patients with carotid and iliac-femoral atherosclerotic disease, COR-IF group consists of patients with coronary and iliac-femoral atherosclerotic disease, and COR-CAR-IF group consists of patients with atherosclerotic disease in three vascular beds: coronary, carotid and iliac-femoral. We followed clinical variables: age, gender, arterial hypertension, tobacco smoking, total cholesterol and diabetes mellitus with focus on arterial hypertension and diabetes mellitus. Results: we had signii- cant percentage of patients with arterial hypertension in all four groups in relation to those with normal blood pressure. Hypertension in male subjects was signiicantly higher in those with polyvascular disease i.e. COR-CAR- IF, and COR-IF groups, compared to monovascular disease i.e. COR group, (p<0.05). In females the prevalence of hypertension was signiicantly higher in COR-CAR-IF and COR-IF groups, (<0.05). Males had higher systolic values in the COR-CAR-IF group compared to other groups, but only signif. difer. was between COR-CAR-IF group vs. CAR-IF group, (p<0.05). In females we found signif. difer. in systolic values in COR-CAR-IF group compared to COR group, p<0,05. In diastolic values we found no signif. difer. between groups. he signiicant percentage of diabetics was in COR-CAR-IF group (77.5%), and the diference to other groups was statistically signiicant, p<0,05. We found signiicant percentage of diabetics in COR-CAR-IF group (77.5%), and the diference between the diabetics versus non-diabetics was statistically signiicant. he largest percentage of diabetics both men (76.1%) and women (84.2%) belonged to the patients with polyvascular disease i.e. COR-CAR-IF group respondents. Conclusions: prevalence of arterial hyper- tension and type 2 diabetes mellitus was statistically higher in individuals with polyvascular atherosclerotic disease. Keywords: hypertension, diabetes mellitus, polyvascular ath- erosclerotic disease Corresponding author: Mirza Dilic, MD, PhD, Clinic of Vascular Diseases, Clinical Center University of Sarajevo, 71000 Sarajevo, Bolnicka 25, B&H, Phone: + 387 33 442 807, email: mdilic@bih.net.ba 1. INTRODUCTION Polyvascular atherosclerotic dis- ease involves presence of atheroscle- rotic process in coronary, carotid and peripheral arteries of the lower extremi- ties (1,2). here are no accurate data on the incidence of atherosclerosis, but all epidemiological data suggests worlwide burden of clinical manifestations of ath- erosclerosis, i.e. coronary heart disease, cerebrovascular disease and peripheral vascular diseases. Atherosclerosis is a complex disease with many predisposing factors that are called multiple risk factors (MRF) i.e. age, gender, arterial hypertension, to- bacco smoking, hyperlipidaemia, obe- sity, diabetes mellitus (3, 4). Epidemi- ological studies have unambiguously shown that hypertension is major risk factor for cardiovascular disease. High blood pressure can be well in advance indicator of cardiovascular cases, in- cluding monovascular atherosclerotic