J Neurol (2005) 252 : 412–416 DOI 10.1007/s00415-005-0659-5 ORIGINAL COMMUNICATION Jaume Roquer Ana Rodríguez Campello Meritxell Gomis Angel Ois Victor Puente Elvira Munteis Previous antiplatelet therapy is an independent predictor of 30-day mortality after spontaneous supratentorial intracerebral hemorrhage JON 1659 Introduction Many studies have focused on the analysis of outcome predictors in patients suffering a spontaneous intra- cerebral hemorrhage (ICH). Some factors such as exten- sive ICH volume [4, 6–10, 12, 15, 21, 25–28, 31, 32], level of consciousness [2, 7–9, 12, 13, 25, 28], patients’ age [6, 8, 10, 12, 13, 15, 17, 29], ventricular extension [5–7, 12, 15, 29] or low Glasgow Scale Score values at admission [3, 4, 15, 17, 21] have been consistently described as strong predictors of negative outcome. Other factors such as high blood glucose levels on admission [9, 32], high blood pressure [9, 32], vomiting [9], past history of dia- betes mellitus [1] or ischemic heart disease [3, 25]), amount of alcohol consumed within 1 week prior to ICH [17], location of the ICH [11, 17, 21, 29, 32], limb paresis [2, 6, 12], language disorders [6]), anticoagulant treat- ment [31], high NIHSS score [5], subarachnoid exten- sion [5], narrow pulse pressure [5], pineal gland dis- placement on CT [32], eye and motor score on the Glasgow Coma Scale [32], midline shift [12], surgical treatment [29], hypertension as only etiology [29] or volume of ventricular blood [33] have been occasionally described as negative outcome predictors. The aim of this study was to determine the indepen- dent factors related to 30-day mortality in a prospective series of patients with spontaneous supratentorial ICH, ■ Abstract Background Intracere- bral hemorrhage (ICH) constitutes 10 % to 15 % of all strokes. Despite several existing outcome predic- tion models for ICH, there are some factors with equivocal value as well as others that still have not been evaluated. Patients and meth- Received: 5 July 2004 Received in revised form: 4 September 2004 Accepted: 8 September 2004 Published online: 3 March 2005 J. Roquer, MD, PhD () · A. Rodríguez Campello, MD · M. Gomis, MD · A. Ois, MD · V. Puente, MD · E. Munteis, MD Unitat d’Ictus Servei de Neurología Hospital del Mar Passeig Marítim 25–29 08003 Barcelona, Spain Tel.: + 34-932483000 E-Mail: 35826@imas.imim.es ods All patients with first ever supratentorial ICH presenting to our institution between December 1995 and December 2002 were prospectively enrolled into the study. Patients with historic modi- fied Rankin Scale > 2 and those un- der anticoagulant treatment or with multiple ICH were excluded. The following parameters were an- alyzed in 194 consecutive patients: age, gender, past history of hyper- tension, diabetes mellitus, hyper- cholesterolemia, past history of ischemic stroke, presence of ischemic heart disease or cardio- embolic disease, current anti- platelet treatment, current alcohol overuse, smoking, Glasgow Coma Scale score (GSS) at admission, vol- ume and location (deep or lobar) of ICH, ventricular extension, glycemia and temperature at ad- mission, and leukoaraiosis.We cor- related these data with the 30-day mortality identifying the indepen- dent predictors by logistic regres- sion analysis. Results Factors inde- pendently associated with 30-day mortality were: age, Glasgow Coma Scale score at admission, ICH vol- ume, ventricular extension, glucose level at admission, and previous antiplatelet use. Conclusions Apart from the classical outcome predic- tors, the previous use of an- tiplatelet agents and the glucose value at admission are independent predictors of 30-day mortality in patients suffering a supratentorial ICH. ■ Key words intracerebral hemorrhage · outcome · antiplatelet agents · glycemia · hemorrhage volume