Implications of human genome architecture for rearrangement based disorders: the genomic basis of disease Christine J. Shaw 1 and James R. Lupski 1,2,3 1 Department of Molecular and Human Genetics, 2 Department of Pediatrics, Baylor College of Medicine, and 3 Texas Children’s Hospital Correspondence should be addressed to J.R.L.: One Baylor Plaza, Room 604B Houston, Texas, 77030 email: jlupski@bcm.tmc.edu phone: (713)798-6530 fax: (713)798-5073 Copyright © 2004 Oxford University Press HMG Advance Access published February 5, 2004 by guest on June 13, 2016 http://hmg.oxfordjournals.org/ Downloaded from